Document Detail


Ethnic differences in left ventricular remodeling in highly-trained athletes relevance to differentiating physiologic left ventricular hypertrophy from hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  18534273     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The purpose of this study was to evaluate ethnic differences in left ventricular (LV) remodeling between highly-trained athletes of African/Afro-Caribbean (black) and Caucasian (white) athletes. BACKGROUND: The upper limits of left ventricular hypertrophy (LVH) are established in white athletes and aid the differentiation of physiologic LVH from hypertrophic cardiomyopathy (HCM). However, there are few data regarding LV remodeling in black athletes, in whom deaths from HCM are more prevalent. METHODS: Between 2003 and 2007, 300 nationally ranked black male athletes (mean age 20.5 years) underwent 12-lead electrocardiogram and 2-dimensional echocardiography. The results were compared with 150 black and white sedentary individuals and 300 highly-trained white male athletes matched for age, size, and sport. RESULTS: Black athletes exhibited greater LV wall thickness and cavity size compared with sedentary black and white individuals. Black athletes had greater LV wall thickness compared with white athletes (11.3 +/- 1.6 mm vs. 10 +/- 1.5 mm; p < 0.001). In absolute terms, 54 black athletes (18%) had LV wall thickness >12 mm compared with 12 white athletes (4%), and 3% of black athletes exhibited LV wall thickness >/=15 mm compared with none of the white athletes. Black athletes with LVH displayed an enlarged LV cavity and normal diastolic function. CONCLUSIONS: Black athletes develop a greater magnitude of LVH compared with white athletes; therefore, extrapolation of conclusions derived from white athletes has the potential of generating false-positive diagnoses of HCM in black athletes.
Authors:
Sandeep Basavarajaiah; Araceli Boraita; Gregory Whyte; Mathew Wilson; Lorna Carby; Ajay Shah; Sanjay Sharma
Related Documents :
25222843 - Common features and differences of the hypothalamic-pituitary-gonadal axis in male and ...
8483643 - Changes in body size of elite high school football players: 1963-1989.
15919483 - Average p/f ratio during donor management for finding out the potential donor of lung p...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  51     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-06     Completed Date:  2008-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2256-62     Citation Subset:  AIM; IM    
Affiliation:
King's College Hospital, London, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
African Americans* / statistics & numerical data
Algorithms
Cardiomyopathy, Hypertrophic / epidemiology,  ethnology*,  ultrasonography
Case-Control Studies
European Continental Ancestry Group* / statistics & numerical data
Heart Ventricles / ultrasonography*
Humans
Hypertrophy, Left Ventricular / epidemiology,  ethnology*,  ultrasonography
Male
Questionnaires
Reference Values
Sports*
United States / epidemiology
Ventricular Remodeling*
Comments/Corrections
Comment In:
J Am Coll Cardiol. 2008 Jun 10;51(23):2263-5   [PMID:  18534274 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Relation of race to electrocardiographic patterns in elite American football players.
Next Document:  Abnormal sympathetic innervation of viable myocardium and the substrate of ventricular tachycardia a...