Document Detail


Ethnic differences in carotid artery diameter and stiffness: the Northern Manhattan Study.
MedLine Citation:
PMID:  21906739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Race/ethnic differences in carotid arterial function and structure exist among those with cerebrovascular disease, but whether differences persist among healthy populations is unknown. Our objective was to investigate differences in carotid artery diameter and stiffness between race/ethnic groups, and examine whether these race/ethnic differences were age-dependent.
METHODS: Carotid diameters were assessed by B-mode ultrasound among 1536 participants from the Northern Manhattan Study (NOMAS), and carotid stiffness metrics were calculated. We used multivariable linear regression models to determine the relationship between race/ethnicity and both carotid arterial stiffness and carotid diastolic diameter.
RESULTS: Mean participant age was 70 ± 9 years (Hispanics = 68 ± 8, blacks = 72 ± 9, and whites = 74 ± 9, p < 0.0001). Mean DDIAM was 6.2 ± 1.0mm (Hispanics = 6.2 ± 0.9 mm, blacks = 6.3 ± 1.0 mm, and whites = 6.3 ± 1.0 mm, p < 0.005) and mean STIFF was 8.7 ± 6.3 (Hispanics = 8.5 ± 5.7, blacks = 9.2 ± 6.2 and whites = 8.9 ± 6.9, p < 0.02). In a model that adjusted for sociodemographics and vascular risk factors including hypertension, diabetes, dislipidemia, renal function, physical acticity and a history of known coronary artery diseases; age was positively associated with greater DDIAM in Hispanics (p < 0.0001) but not among blacks or whites. Older age was associated with greater stiffness among Hispanics (p < 0.0001) and blacks (p < 0.003), but not among whites.
CONCLUSIONS: We found race/ethnic differences in the association between age and arterial stiffness and diameter, including age-dependent arterial dilation observed in Hispanics that was not observed among blacks or whites.
Authors:
Matthew S Markert; David Della-Morte; Digna Cabral; Eugene L Roberts; Hannah Gardener; Chuanhui Dong; Clinton B Wright; Mitchell S V Elkind; Ralph L Sacco; Tatjana Rundek
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-08-22
Journal Detail:
Title:  Atherosclerosis     Volume:  219     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-29     Completed Date:  2012-04-05     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  827-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA.
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MeSH Terms
Descriptor/Qualifier:
African Americans / statistics & numerical data*
Age Factors
Aged
Analysis of Variance
Atherosclerosis / ethnology*,  pathology,  ultrasonography
Carotid Arteries / pathology*,  ultrasonography
Carotid Artery Diseases / ethnology*,  pathology,  ultrasonography
Cross-Sectional Studies
Elasticity
European Continental Ancestry Group / statistics & numerical data*
Female
Hispanic Americans / statistics & numerical data*
Humans
Linear Models
Male
Middle Aged
New York City / epidemiology
Prospective Studies
Risk Assessment
Risk Factors
Grant Support
ID/Acronym/Agency:
K24 NS062737/NS/NINDS NIH HHS; K24 NS062737-02/NS/NINDS NIH HHS; R01 NS065114/NS/NINDS NIH HHS; R37 NS029993/NS/NINDS NIH HHS; R37 NS029993-17/NS/NINDS NIH HHS
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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