Document Detail


Ethnic differences in breast cancer risk and survival: A study on immigrants in Sweden.
MedLine Citation:
PMID:  23317144     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background. There are large geographic differences in breast cancer risk but whether survival differs between low- and high-risk groups is less well-established. As the survival of cancer depends on the level of healthcare and awareness of disease risks, subtle differences in cancer biology cannot be revealed in international comparisons. Instead, comparison of diverse immigrant groups in a country of uniformly accessible healthcare system should enable conclusions to be made about ethnic determinants of cancer risk and survival. Material and methods. The Swedish Family-Cancer Database was used to calculate standardized incidence (SIRs) and hazard ratios (HRs) of death from female breast cancer in 12 505 and 137 547 patients diagnosed with breast cancer among immigrants and Swedes, respectively. The ratios were adjusted for age, period, region, parity, and age at first childbirth. Ordinal logistic regression analysis was used to estimate odds ratios (ORs) for the clinical TNM classes. The analyses were stratified by menopausal status and histology. Results. Turks, Southeast Asians, and Chileans had the lowest breast cancer risk (SIR = 0.44; 95% CI 0.37-0.51) and Iraqis the highest risk (1.19; 1.05-1.35), mainly due to premenopausal cancer (1.51; 1.27-1.78). The HRs for all breast cancers were between 0.98 (0.81-1.18) (low-risk Europeans) and 1.24 (0.94-1.63) (lowest-risk non-Europeans), but were not significant. No differences in survival of ductal carcinoma between immigrants and Swedes were found, while low-risk non-Europeans had a HR of 2.88 (1.37-6.08) for lobular carcinoma. Low-risk non-Europeans were diagnosed in a higher T-class (OR = 1.87; 1.21-2.87) than Swedes. Conclusion. We did not find any evidence that ethnic differences in breast cancer risk substantially affect the survival. The observed poor survival of some low-risk immigrants in lobular carcinoma may be related to treatment. The tendency of low-risk immigrants to present with higher T-class compared to Swedes may depend on their lower participation in the mammography screening program.
Authors:
Seyed Mohsen Mousavi; Asta Försti; Jan Sundquist; Kari Hemminki
Related Documents :
24527034 - Breast cancer pathology, receptor status, and patterns of metastasis in a rural appalac...
8675434 - Clusterlike headache as a first sign of brain metastases of lung cancer.
25023044 - Postoperative tamoxifen for ductal carcinoma in situ: cochrane systematic review and me...
24578894 - Factors predicting gleason score 6 upgrading after radical prostatectomy.
8040464 - Adenocarcinoma of the mammary-like glands of the vulva: a concept unifying sweat gland ...
10772414 - Nonsteroidal anti-inflammatory drugs (nsaids) in the prevention of colorectal cancer.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  Acta oncologica (Stockholm, Sweden)     Volume:  -     ISSN:  1651-226X     ISO Abbreviation:  Acta Oncol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709065     Medline TA:  Acta Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg , Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The lymph node ratio as a prognostic factor for gastric cancer.
Next Document:  Hypoxia-targeted radiotherapy dose painting for head and neck cancer using (18)F-FMISO PET: A biolog...