Document Detail


Ethnic differences in adrenocorticotropic hormone, cortisol and corticotropin-releasing hormone during pregnancy.
MedLine Citation:
PMID:  17537545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Significant ethnic disparities exist in reproductive outcomes. A potential contributing factor may be the functioning of the hypothalamic-pituitary-adrenal (HPA) axis and placenta during pregnancy. In the present study, levels of cortisol, ACTH and CRH were determined longitudinally from the plasma of 310 African American, Hispanic and non-Hispanic White women at 18-20, 24-26 and 30-32 weeks' gestation. During pregnancy, African American women exhibited lower levels of cortisol than non-Hispanic women and higher levels of ACTH than Hispanic women. The trajectory of CRH increase also differed by ethnicity, with African Americans exhibiting the lowest levels both early and late in pregnancy. Higher levels of cortisol at 18-20 weeks were associated with higher levels of CRH at 30-32 weeks among the African American and Hispanic women, but not among non-Hispanic women. Ethnic differences persisted when adjusting statistically for sociodemographic and biomedical factors. The findings are consistent with the possibility that ethnic disparities in adverse birth outcomes may be due, in part, to differences in HPA axis and placental function.
Authors:
Laura M Glynn; Christine Dunkel Schetter; Aleksandra Chicz-DeMet; Calvin J Hobel; Curt A Sandman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2007-04-19
Journal Detail:
Title:  Peptides     Volume:  28     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-05     Completed Date:  2007-09-05     Revised Date:  2011-04-21    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1155-61     Citation Subset:  IM    
Affiliation:
Department of Psychiatry & Human Behavior, University of California, Irvine, CA 92868, United States. lglynn@uci.edu
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / blood*
African Americans
African Continental Ancestry Group*
Corticotropin-Releasing Hormone / blood*
European Continental Ancestry Group*
Female
Gestational Age
Hispanic Americans*
Humans
Hydrocortisone / blood*
Pregnancy
Pregnancy Trimester, First
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Grant Support
ID/Acronym/Agency:
NS-41298/NS/NINDS NIH HHS; R01 HD-28413/HD/NICHD NIH HHS; R01 HD-40967/HD/NICHD NIH HHS; R01 HD028413-08/HD/NICHD NIH HHS; R01 NS041298-05/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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