Document Detail

Ethnic considerations in the treatment of Hispanic and Latin-American patients with hyperpigmentation.
MedLine Citation:
PMID:  17176299     Owner:  NLM     Status:  MEDLINE    
Latin-Americans have a heterogeneous ancestry that is defined by their place of domicile, while Hispanics are defined as those persons of Spanish descent. These two groups have a diverse range of skin phototypes and pigmentation and are prone to an increased incidence of melasma and post-inflammatory hyperpigmentation. Little research has been conducted to evaluate the frequency, course, effects, tolerability and treatment response of skin diseases in Hispanic and Latin-American populations. From the limited data that are available it is considered that the treatment of melasma in these two groups does not differ from the general population. First-line therapy of melasma should consist of effective topical therapies, mainly a fixed triple combination of hydroquinone, retinoic acid and fluocinolone acetonide. Where patients have either sensitivity or triple combination therapy is unavailable, other compounds with dual ingredients may be considered as an alternative. Options for second-line therapy include peels either alone or in combination with topical therapy. Lasers should rarely be used in the treatment of melasma and then only as third-line therapy in cases of melasma which is resistant to all other therapies. If applied, skin type must be taken into account. Irritation and sensitivity can be a concern in darker-skinned Hispanic patients and for this reason, the risk of post-inflammatory hyperpigmentation (PIH) following treatment should be considered.
D Hexsel; I Arellano; M Rendon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  156 Suppl 1     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-19     Completed Date:  2007-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  7-12     Citation Subset:  IM    
School of Medicine, University of Passo Fundo, Rio Grande do Sol, Brazil.
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MeSH Terms
Administration, Topical
Drug Therapy, Combination
Facial Dermatoses / diagnosis,  drug therapy,  ethnology
Fluocinolone Acetonide / analogs & derivatives,  therapeutic use
Glucocorticoids / therapeutic use
Hispanic Americans / ethnology
Hydroquinones / therapeutic use
Hyperpigmentation / diagnosis,  drug therapy,  ethnology*
Keratolytic Agents / therapeutic use
Latin America / ethnology
Salicylic Acid / therapeutic use
Skin Pigmentation*
Tretinoin / therapeutic use
Reg. No./Substance:
0/Glucocorticoids; 0/Hydroquinones; 0/Keratolytic Agents; 123-31-9/hydroquinone; 302-79-4/Tretinoin; 67-73-2/Fluocinolone Acetonide; 69-72-7/Salicylic Acid; 807-38-5/fluocinolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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