| Ethinyl estradiol and medroxyprogesterone acetate in patients with epithelial ovarian carcinoma: a phase II study. | |
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MedLine Citation:
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PMID: 2937533 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with ovarian carcinoma refractory to chemotherapy received a sequential combination of ethinyl estradiol and medroxyprogesterone acetate in two dose regimens. There was no difference in therapeutic activity of the two dose regimens. Of 65 patients, nine (14%) responded to treatment and 13 (20%) had stable disease. Vascular complications occurred in three patients; hemiplegia developed in one of those. Nine patients had significant nausea and vomiting, and one experienced severe depression that required treatment withdrawal. The sequential and combined use of ethinyl estradiol and medroxyprogesterone acetate may provide an alternative treatment for certain patients with ovarian carcinoma that does not respond to optimum chemotherapy. Additional studies are required to determine if synergism exists between this treatment and other modalities of therapy. Further investigation is required into the vascular disorders that complicate therapy to determine whether appropriate preventive measures are possible. |
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Authors:
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R S Freedman; P B Saul; C L Edwards; C J Jolles; D M Gershenson; L A Jones; E N Atkinson; W J Dana |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer treatment reports Volume: 70 ISSN: 0361-5960 ISO Abbreviation: Cancer Treat Rep Publication Date: 1986 Mar |
Date Detail:
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Created Date: 1986-05-19 Completed Date: 1986-05-19 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7607107 Medline TA: Cancer Treat Rep Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 369-73 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antineoplastic Combined Chemotherapy Protocols / adverse effects, therapeutic use* Ethinyl Estradiol / administration & dosage Female Humans Medroxyprogesterone / administration & dosage, analogs & derivatives Medroxyprogesterone Acetate Middle Aged Ovarian Neoplasms / drug therapy* Receptors, Estrogen / analysis Receptors, Progesterone / analysis Vascular Diseases / chemically induced |
| Grant Support | |
ID/Acronym/Agency:
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CA-31382/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Estrogen; 0/Receptors, Progesterone; 520-85-4/Medroxyprogesterone; 57-63-6/Ethinyl Estradiol; 71-58-9/Medroxyprogesterone Acetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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