Document Detail

Ethical issues in stem cell research.
MedLine Citation:
PMID:  19366754     Owner:  NLM     Status:  MEDLINE    
Stem cell research offers great promise for understanding basic mechanisms of human development and differentiation, as well as the hope for new treatments for diseases such as diabetes, spinal cord injury, Parkinson's disease, and myocardial infarction. However, human stem cell (hSC) research also raises sharp ethical and political controversies. The derivation of pluripotent stem cell lines from oocytes and embryos is fraught with disputes about the onset of human personhood. The reprogramming of somatic cells to produce induced pluripotent stem cells avoids the ethical problems specific to embryonic stem cell research. In any hSC research, however, difficult dilemmas arise regarding sensitive downstream research, consent to donate materials for hSC research, early clinical trials of hSC therapies, and oversight of hSC research. These ethical and policy issues need to be discussed along with scientific challenges to ensure that stem cell research is carried out in an ethically appropriate manner. This article provides a critical analysis of these issues and how they are addressed in current policies.
Bernard Lo; Lindsay Parham
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2009-04-14
Journal Detail:
Title:  Endocrine reviews     Volume:  30     ISSN:  1945-7189     ISO Abbreviation:  Endocr. Rev.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-12     Completed Date:  2009-07-23     Revised Date:  2013-03-14    
Medline Journal Info:
Nlm Unique ID:  8006258     Medline TA:  Endocr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  204-13     Citation Subset:  IM    
University of California San Francisco Program in Medical Ethics, San Francisco, California 94143, USA.
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MeSH Terms
Embryo Research / ethics*
Embryonic Stem Cells*
Ethics, Institutional
Ethics, Research
Pluripotent Stem Cells*
Grant Support
1 UL1 RR024131-01/RR/NCRR NIH HHS

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