Document Detail


Ethical considerations in presymptomatic testing for variant CJD.
MedLine Citation:
PMID:  16269554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Variant Creutzfeldt-Jakob disease (vCJD) is a fatal, transmissible, neurodegenerative disorder for which there is currently no effective treatment. vCJD arose from the zoonotic spread of bovine spongiform encephalopathy. There is now compelling evidence for human to human transmission through blood transfusions from presymptomatic carriers and experts are warning that the real epidemic may be yet to come. Imperatives exist for the development of reliable, non-invasive presymptomatic diagnostic tests. Research into such tests is well advanced. In this article the ethical implications of the availability of these tests are elaborated and comparisons drawn with predictive genetic testing for Huntington's disease and screening for HIV. Paramount to considerations is the issue of whom to test, weighing up respect for personal autonomy against obligations to benefit and protect society. A paradigm is proposed similar to that used for HIV screening but with unique features: compulsory testing of all blood/organ donors and individuals undergoing surgery or invasive procedures who have a significant risk of disease transmission.
Authors:
R E Duncan; M B Delatycki; S J Collins; A Boyd; C L Masters; J Savulescu
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of medical ethics     Volume:  31     ISSN:  0306-6800     ISO Abbreviation:  J Med Ethics     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-04     Completed Date:  2006-02-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7513619     Medline TA:  J Med Ethics     Country:  England    
Other Details:
Languages:  eng     Pagination:  625-30     Citation Subset:  E; IM    
Affiliation:
Murdoch Children's Research Institute and the Bruce Lefroy Centre for Genetic Health Research, Royal Children's Hospital, Parkville, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Clinical Protocols
Creutzfeldt-Jakob Syndrome / diagnosis*,  transmission
Decontamination / methods
Disease Outbreaks
Ethics, Clinical*
Genetic Predisposition to Disease
HIV Infections / diagnosis
Humans
Huntington Disease / diagnosis,  genetics
Prions
Zoonoses
Chemical
Reg. No./Substance:
0/Prions
Comments/Corrections

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