| Ethical challenges in cancer research in children. | |
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MedLine Citation:
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PMID: 18055854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical research has led to great advances in cancer therapy for children, and a greater proportion of children than adults with cancer participate in clinical trials. Despite this success, there remain important ethical challenges in conducting this research. There are challenges in obtaining informed consent and assent when children are research subjects; challenges arising from study design issues in phase III, II, or I clinical trials; and challenges related to the development of new classes of drugs, especially molecularly targeted therapies. It is important for researchers and clinicians to understand these challenges so that progress in cancer treatment is achieved in a sound ethical and regulatory fashion. |
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Authors:
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Stacey L Berg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The oncologist Volume: 12 ISSN: 1083-7159 ISO Abbreviation: Oncologist Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-03-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607837 Medline TA: Oncologist Country: United States |
Other Details:
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Languages: eng Pagination: 1336-43 Citation Subset: IM |
Affiliation:
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Texas Children's Cancer Center, 6621 Fannin Street, MC3-3320, Houston, Texas 77030, USA. sberg@txccc.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Clinical Trials as Topic Ethics, Medical* Ethics, Research Human Experimentation Humans Informed Consent Medical Oncology / methods* Neoplasms / ethnology*, therapy* Risk Treatment Outcome |
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