Document Detail


Ethical challenges in cancer research in children.
MedLine Citation:
PMID:  18055854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical research has led to great advances in cancer therapy for children, and a greater proportion of children than adults with cancer participate in clinical trials. Despite this success, there remain important ethical challenges in conducting this research. There are challenges in obtaining informed consent and assent when children are research subjects; challenges arising from study design issues in phase III, II, or I clinical trials; and challenges related to the development of new classes of drugs, especially molecularly targeted therapies. It is important for researchers and clinicians to understand these challenges so that progress in cancer treatment is achieved in a sound ethical and regulatory fashion.
Authors:
Stacey L Berg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The oncologist     Volume:  12     ISSN:  1083-7159     ISO Abbreviation:  Oncologist     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607837     Medline TA:  Oncologist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1336-43     Citation Subset:  IM    
Affiliation:
Texas Children's Cancer Center, 6621 Fannin Street, MC3-3320, Houston, Texas 77030, USA. sberg@txccc.org
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MeSH Terms
Descriptor/Qualifier:
Child
Clinical Trials as Topic
Ethics, Medical*
Ethics, Research
Human Experimentation
Humans
Informed Consent
Medical Oncology / methods*
Neoplasms / ethnology*,  therapy*
Risk
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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