| Ethical research in delirium: arguments for including decisionally incapacitated subjects. | |
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MedLine Citation:
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PMID: 19247810 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Here we describe how more important findings were obtained in a delirium study by using an informal assessment of mental capacity, and, in those who lacked capacity, obtaining consent later when or if capacity returned or a proxy was found. From a total of 233 patients 23 patients lacked capacity as judged by our informal capacity judgment and 210 did not. Of those who lacked capacity, 13 agreed to enter in the study. Six of them regained capacity later. When these 13 participants were excluded from analysis, significant findings were no longer evident. These results show that by the inclusion of subjects who lacked capacity the results of analyses of the condition from whish they suffer are altered. We suggest that this approach to the study of delirium is more ethical than the usual system of strict exclusion of people who lack capacity to give consent and for whom assent is not available. |
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Authors:
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Dimitrios Adamis; Adrian Treloar; Finbarr C Martin; Alastair J D Macdonald |
Publication Detail:
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Type: Journal Article Date: 2009-02-27 |
Journal Detail:
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Title: Science and engineering ethics Volume: 16 ISSN: 1471-5546 ISO Abbreviation: Sci Eng Ethics Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-05 Completed Date: 2010-07-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9516228 Medline TA: Sci Eng Ethics Country: England |
Other Details:
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Languages: eng Pagination: 169-74 Citation Subset: E; IM |
Affiliation:
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Research and Academic Institute of Athens, 27 Themistokleous Street & Akadimias, Athens 106 77, Greece. dimaadamis@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Biomedical Research / ethics* Codes of Ethics Decision Making / ethics Delirium* / diagnosis Double Effect Principle Female Geriatric Assessment Guidelines as Topic Humans Informed Consent / ethics* Judgment / ethics Male Mental Competency* Mental Status Schedule Patient Rights / ethics Patient Selection / ethics* Principle-Based Ethics Research Subjects* Severity of Illness Index Statistics, Nonparametric |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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