Document Detail

Ethenzamide-gentisic acid-acetic acid (2/1/1).
MedLine Citation:
PMID:  21579106     Owner:  NLM     Status:  PubMed-not-MEDLINE    
In the title co-crystal solvate, 2-ethoxy-benzamide-2,5-dihydroxy-benzoic acid-ethanoic acid (2/1/1), 2C(9)H(11)NO(2)·C(7)H(6)O(4)·C(2)H(4)O(2), two nonsteroidal anti-inflammatory drugs, ethenzamide (systematic name: 2-ethoxy-benzamide) and gentisic acid (systematic name: 2,5-dihydroxy-benzoic acid), together with acetic acid (systematic name: ethanoic acid) form a four-component mol-ecular assembly held together by N-H⋯O and O-H⋯O hydrogen bonds. This assembly features two symmetry-independent mol-ecules of ethenzamide, forming supra-molecular acid-amide heterosynthons with gentisic acid and acetic acid. These heterosynthons involve quite strong O-H⋯O [O⋯O = 2.5446 (15) and 2.5327 (15) Å] and less strong N-H⋯O [N⋯O = 2.9550 (17) and 2.9542 (17) Å] hydrogen bonds. The overall crystal packing features several C-H⋯O and π-π stacking inter-actions [centroid-centroid distance = 3.7792 (11) Å].
Srinivasulu Aitipamula; Pui Shan Chow; Reginald B H Tan
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Publication Detail:
Type:  Journal Article     Date:  2010-04-10
Journal Detail:
Title:  Acta crystallographica. Section E, Structure reports online     Volume:  66     ISSN:  1600-5368     ISO Abbreviation:  Acta Crystallogr E Struct Rep Online     Publication Date:  2010  
Date Detail:
Created Date:  2011-05-17     Completed Date:  2011-07-14     Revised Date:  2011-11-11    
Medline Journal Info:
Nlm Unique ID:  101089178     Medline TA:  Acta Crystallogr E Struct Rep Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  o1045-6     Citation Subset:  -    
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