| Ethenzamide-gentisic acid-acetic acid (2/1/1). | |
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MedLine Citation:
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PMID: 21579106 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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In the title co-crystal solvate, 2-ethoxy-benzamide-2,5-dihydroxy-benzoic acid-ethanoic acid (2/1/1), 2C(9)H(11)NO(2)·C(7)H(6)O(4)·C(2)H(4)O(2), two nonsteroidal anti-inflammatory drugs, ethenzamide (systematic name: 2-ethoxy-benzamide) and gentisic acid (systematic name: 2,5-dihydroxy-benzoic acid), together with acetic acid (systematic name: ethanoic acid) form a four-component mol-ecular assembly held together by N-H⋯O and O-H⋯O hydrogen bonds. This assembly features two symmetry-independent mol-ecules of ethenzamide, forming supra-molecular acid-amide heterosynthons with gentisic acid and acetic acid. These heterosynthons involve quite strong O-H⋯O [O⋯O = 2.5446 (15) and 2.5327 (15) Å] and less strong N-H⋯O [N⋯O = 2.9550 (17) and 2.9542 (17) Å] hydrogen bonds. The overall crystal packing features several C-H⋯O and π-π stacking inter-actions [centroid-centroid distance = 3.7792 (11) Å]. |
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Authors:
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Srinivasulu Aitipamula; Pui Shan Chow; Reginald B H Tan |
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Publication Detail:
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Type: Journal Article Date: 2010-04-10 |
Journal Detail:
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Title: Acta crystallographica. Section E, Structure reports online Volume: 66 ISSN: 1600-5368 ISO Abbreviation: Acta Crystallogr E Struct Rep Online Publication Date: 2010 |
Date Detail:
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Created Date: 2011-05-17 Completed Date: 2011-07-14 Revised Date: 2011-11-11 |
Medline Journal Info:
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Nlm Unique ID: 101089178 Medline TA: Acta Crystallogr E Struct Rep Online Country: England |
Other Details:
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Languages: eng Pagination: o1045-6 Citation Subset: - |
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