Document Detail


Ethanolic and aqueous extracts derived from Australian fungi inhibit cancer cell growth in vitro.
MedLine Citation:
PMID:  21262985     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Fifteen Australian macrofungi were investigated for cytotoxic activity. Ethanol, cold and hot water extracts of each species were screened for cytotoxic activity against normal mouse fibroblast cells (NIH/3T3), healthy human epithelial kidney cells (HEK-293) and four cancer cell lines; gastric adenocarcinoma cells (AGS), two mammary gland adenocarcinoma cells (MDA-MB-231, MCF7) and colorectal adenocarcinoma cells (HT-29) using a validated MTT assay. Most extracts derived from Omphalotus nidiformis, Cordyceps cranstounii and Cordyceps gunnii demonstrated significant cytotoxic activity towards a variety of cancer cell lines. In contrast, only some extracts from Coprinus comatus, Cordyceps hawkesii, Hypholoma fasciculare, Lepista nuda, Leratiomyces ceres and Ophiocordyceps robertsii displayed significant cytotoxic activity which was usually selective for only one or two cancer cell lines tested. The least cytotoxic species evaluated in this study were Agaricus bitorquis, Coprinopsis atrametaria, Psathyrella asperospora, Russula clelandii, Tricholoma sp. AU2 and Xerula mundroola.
Authors:
Karren D Beattie; Rahel Ulrich; I Darren Grice; Shaikh J Uddin; Tony Blake; Kyle Wood; Jules Steele; Fontaine Iu; Tom W May; Evelin Tiralongo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-24
Journal Detail:
Title:  Mycologia     Volume:  -     ISSN:  0027-5514     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400764     Medline TA:  Mycologia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Griffith University, School of Pharmacy & Griffith Institute for Health and Medical Research, Gold Coast, QLD.
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