| Ethanol washing does not attenuate the hypocholesterolemic potential of soy protein. | |
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MedLine Citation:
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PMID: 15561488 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: A feeding study in rats investigated the principal active component for the hypocholesterolemic effect of soy protein isolate (SPI) by comparing the effect before and after ethanol washing. METHODS: Five-week-old male Sprague-Dawley rats were fed cholesterol-enriched AIN-93G diets containing 20% casein (CAS), 20% SPI, 20% ethanol-washed SPI (EWS), 18.4% EWS plus 1.6% ethanol extract (EE), or 20% CAS plus 1.6% EE for 2 wk. RESULTS: Plasma cholesterol concentrations in rats fed EWS and SPI were comparable and were significantly lower than those in rats fed CAS. The addition of EE to EWS and CAS did not influence plasma cholesterol level. Fecal steroid excretion of the three SPI groups was higher than that of the two CAS groups. The addition of EE to EWS and CAS showed a tendency to increase acidic steroid and decrease neutral steroid. CONCLUSIONS: In this experiment which used identifiable protein preparations, a significant fraction of the cholesterol-lowering effect of SPI in rats was attributed to its protein component but not to the ethanol-extractable minor constituents including isoflavones. |
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Authors:
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Kensuke Fukui; Nobuhiko Tachibana; Youichi Fukuda; Kiyoharu Takamatsu; Michihiro Sugano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 20 ISSN: 0899-9007 ISO Abbreviation: Nutrition Publication Date: 2004 Nov-Dec |
Date Detail:
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Created Date: 2004-11-24 Completed Date: 2005-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802712 Medline TA: Nutrition Country: United States |
Other Details:
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Languages: eng Pagination: 984-90 Citation Subset: IM |
Affiliation:
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Food Science Research Institute, Fuji Oil Co., Ltd., Osaka, Japan. 910293@so.fujioil.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / chemistry, pharmacology*, therapeutic use Cholesterol / blood* Ethanol / adverse effects* Feces / chemistry Hypercholesterolemia / drug therapy Isoflavones / analysis Male Random Allocation Rats Rats, Sprague-Dawley Soybean Proteins / chemistry, pharmacology*, therapeutic use Steroids / analysis |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Isoflavones; 0/Soybean Proteins; 0/Steroids; 57-88-5/Cholesterol; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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