Document Detail

Ethanol lock therapy to treat tunnelled central venous catheter-associated blood stream infections: results from a prospective trial.
MedLine Citation:
PMID:  18418801     Owner:  NLM     Status:  MEDLINE    
In order to assess the efficacy of 70% ethanol locks in addition to antibiotic therapy to treat tunnelled central venous catheter-associated bloodstream infections, a pilot study of 19 patients was performed prospectively using ethanol locks for 5 d in addition to antibiotic therapy to treat tunnelled central venous catheter-associated bacteraemia. 12 patients had mono-microbial infections and 7 had polymicrobial isolates. 17 of 19 patients completed ethanol lock therapy. 15 of 17 patients completing ethanol lock therapy had no recurrence of the original organism and retained their catheter for a median of 36 and an average of 47 d following initiation of ethanol lock therapy. These results demonstrate the safety and potential efficacy of this technique against a broad range of potentially virulent organisms. The intervention was acceptable to both staff and patients with no significant side-effects. These preliminary results from our prospective pilot study suggest that ethanol lock therapy is safe and easily integrated into clinical practice, and may have utility in treating central venous catheter-associated infections, avoiding removal of catheters in patients requiring long-term venous access.
Jennifer Broom; Marion Woods; Anthony Allworth; James McCarthy; Joan Faoagali; Sarah Macdonald; Alan Pithie
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  40     ISSN:  0036-5548     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-17     Completed Date:  2008-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  399-406     Citation Subset:  IM    
Infectious Diseases Department, Royal Brisbane and Women's Hospital, Herston, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Anti-Infective Agents / pharmacology*
Bacteremia / drug therapy*,  microbiology
Bacteria / classification,  isolation & purification
Catheterization, Central Venous / adverse effects*,  methods
Catheters, Indwelling / microbiology*
Disinfection / methods*
Ethanol / pharmacology*
Middle Aged
Pilot Projects
Prospective Studies
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Infections and antibiotic prescribing in Swedish nursing homes: a cross-sectional study.
Next Document:  Candida albicans versus non-albicans bloodstream infection in patients in a tertiary hospital: an an...