Document Detail


Ethanol intake may modify gossypol toxicosis in the rat.
MedLine Citation:
PMID:  8889787     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Some aspects of the toxicity of gossypol were investigated in ethanol-fed, gossypol-treated Sprague-Dawley rats, with and without protein malnutrition. Serum creatine phosphokinase activity was depressed in all gossypol-treated rats and gossypol caused greater decreases than ethanol in those animals that were fed the normal diet. Even though the adrenal glands were enlarged in all gossypol-treated rats, this was accompanied by depressed serum cortisol levels. Histopathological findings, including vacuolar degeneration of hepatocytes and dilation of the sinusoids in the liver, atrophy and leucocytic infiltration of cardiac myofibres, vacuolation of the renal glomerulus and cellular depletion of the spleen and thymus, were most severe in the protein-malnourished, gossypol-treated rats; these were generally absent in the other groups. These findings indicated that either adequate levels of protein in the diet and/or ethanol consumption have the effect of reducing gossypol toxicity, probably by reducing the amount of gossypol available for tissue exposure through enhanced metabolism and/or clearance from the body. However, an evaluation of the metabolic pathways involved in gossypol metabolism in ethanol-fed individuals might provide a better understanding of these observations.
Authors:
B T Akingbemi; P V Rao; T A Aire
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied toxicology : JAT     Volume:  16     ISSN:  0260-437X     ISO Abbreviation:  J Appl Toxicol     Publication Date:    1996 Sep-Oct
Date Detail:
Created Date:  1997-01-23     Completed Date:  1997-01-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109495     Medline TA:  J Appl Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  375-80     Citation Subset:  IM    
Affiliation:
Department of Preclinical Veterinary Studies, University of Zimbabwe, Mount Pleasant, Harare, Zimbabwe.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / drug effects,  pathology
Analysis of Variance
Animals
Creatine Kinase / blood
Drug Interactions
Ethanol / administration & dosage,  metabolism,  toxicity*
Gossypol / administration & dosage,  metabolism,  toxicity*
Heart / drug effects
Hydrocortisone / blood
Kidney Glomerulus / drug effects,  pathology
Liver / cytology,  drug effects,  pathology
Lung / drug effects,  metabolism,  pathology
Male
Myocardium / metabolism,  pathology
Organ Size / drug effects
Protein Deficiency / physiopathology
Rats
Rats, Sprague-Dawley
Solvents / administration & dosage,  metabolism,  toxicity*
Spleen / cytology,  drug effects,  pathology
Thymus Gland / cytology,  drug effects,  pathology
Tissue Fixation
Chemical
Reg. No./Substance:
0/Solvents; 303-45-7/Gossypol; 50-23-7/Hydrocortisone; 64-17-5/Ethanol; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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