Document Detail

Ethanol-induced myocardial ischemia: close relation between blood acetaldehyde level and myocardial ischemia.
MedLine Citation:
PMID:  8504580     Owner:  NLM     Status:  MEDLINE    
A patient with vasospastic angina who developed myocardial ischemia following ethanol ingestion but not after exercise was described. Myocardial ischemia was evidenced by electrocardiograms (ECGs) and thallium-201 scintigrams. The blood acetaldehyde level after ethanol ingestion was abnormally high. The time course and severity of myocardial ischemia coincided with those of the blood ethanol and acetaldehyde level. Coronary arteriography showed ergonovine maleate-induced coronary vasospasm at the left anterior descending coronary artery. ECG changes similar to those induced by ethanol ingestion were observed at the same time. These findings suggest that the high blood acetaldehyde level might be responsible for the development of coronary vasospasm and myocardial ischemia in this patient.
H Ando; H Abe; R Hisanou
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  16     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-06     Completed Date:  1993-07-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  443-6     Citation Subset:  IM    
Matsuyama Red Cross Hospital, Cardiovascular Division, Japan.
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MeSH Terms
Acetaldehyde / adverse effects,  blood*
Beer / adverse effects
Coronary Angiography
Electrocardiography / drug effects
Epinephrine / blood
Ethanol / adverse effects*,  blood
Exercise Test
Histamine / blood
Myocardial Ischemia / blood,  chemically induced*,  radiography,  radionuclide imaging
Norepinephrine / blood
Serotonin / blood
Thallium Radioisotopes / diagnostic use
Reg. No./Substance:
0/Thallium Radioisotopes; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 51-45-6/Histamine; 64-17-5/Ethanol; 75-07-0/Acetaldehyde

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