Document Detail


Ethanol-induced late fetal death in mice exposed around the time of fertilization.
MedLine Citation:
PMID:  4040604     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the mouse, all autosomal monosomies and trisomies are lethal by the time of birth (Searle, 1981). To test whether ethanol ingested by females shortly after mating induces nondisjunction, as reported by Kaufman (1983) on the basis of cytological evidence, we attempted to determine whether the incidence of intrauterine death was affected by this treatment. The incidence of late death (day 11 postconception or later) was found to be significantly increased when ethanol was administered 2 h following a 30-min mating period, but not when the interval was shorter. Measurements of early death were not sensitive enough (because of the high control frequency) to show an effect of ethanol treatment. Limited cytological data showed an induced incidence of trisomy in line with the excess frequency of late death, but the trisomy incidence by itself was not significantly different from control. The overall level of effect in the present experiment was lower than that reported by Kaufman.
Authors:
W J Washington; K T Cain; N L Cacheiro; W M Generoso
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Mutation research     Volume:  147     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-09-04     Completed Date:  1985-09-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  205-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromosome Aberrations
Ethanol / toxicity*
Female
Fertilization / drug effects
Fetal Death / chemically induced*
Genes, Dominant
Genes, Lethal
Gestational Age
Mice
Mutation / drug effects*
Pregnancy
Chemical
Reg. No./Substance:
64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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