Document Detail


Ethanol-induced apoptosis in the developing visual system during synaptogenesis.
MedLine Citation:
PMID:  12824217     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Ethanol is known to have deleterious effects on the human fetal nervous system (fetal alcohol syndrome), including components of the visual system, but only modest progress has been made in understanding these effects. The authors have recently demonstrated that, during the period of synaptogenesis, a single episode of ethanol intoxication lasting for several hours triggers a massive wave of apoptotic neurodegeneration in several regions of the developing rat or mouse forebrain. The present study was undertaken to determine to what extent the developing visual system is vulnerable to the apoptogenic effects of ethanol. METHODS: Infant rats and mice at ages from birth to 21 days were treated subcutaneously with a single dose of ethanol or with two doses, 2 hours apart, on a single day. Blood alcohol levels were determined, and the retinas and visual centers in the brain were examined by light and electronmicroscopy at various times from 4 to 24 hours after treatment. RESULTS: Retinal ganglion cells and neurons in the lateral geniculate nucleus, superior colliculus, and visual cortex were all highly susceptible to ethanol's apoptogenic action, the period of peak sensitivity being postnatal days 1 to 4 for ganglion cells and 4 to 7 for the other visual neurons. A transient elevation of blood alcohol to approximately 120 mg/dL was sufficient to activate the cell death program in visual neurons. CONCLUSIONS: During synaptogenesis, a single ethanol intoxication episode triggers apoptotic cell death of neurons at all levels of the visual system from retina to the visual cortex.
Authors:
Tatyana Tenkova; Chainllie Young; Krikor Dikranian; Joann Labruyere; John W Olney
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  44     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-25     Completed Date:  2003-08-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2809-17     Citation Subset:  IM    
Affiliation:
Washington University School of Medicine, St. Louis, Missouri 63110, USA.
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MeSH Terms
Descriptor/Qualifier:
Alcohol-Induced Disorders, Nervous System / etiology*,  pathology
Animals
Animals, Newborn
Apoptosis / drug effects*
Cell Count
Ethanol / blood,  toxicity*
Geniculate Bodies / drug effects,  pathology
Mice
Mice, Inbred C57BL
Nerve Degeneration / chemically induced*,  pathology
Neurons / drug effects
Rats
Rats, Sprague-Dawley
Retinal Ganglion Cells / drug effects,  pathology
Superior Colliculi / drug effects,  pathology
Synapses / drug effects*
Visual Cortex / drug effects,  pathology
Visual Pathways / drug effects*,  pathology
Grant Support
ID/Acronym/Agency:
AG11355/AG/NIA NIH HHS; DA05072/DA/NIDA NIH HHS; EY08089/EY/NEI NIH HHS; HD37100/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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