| Ethanol increases defibrillation threshold in pigs. | |
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MedLine Citation:
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PMID: 7681170 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alcohol ingestion has been associated with cardiac arrhythmias and may initiate fibrillation in patients with automatic defibrillators. The effect of alcohol on defibrillation efficacy is unknown. To assess the acute effects of alcohol on defibrillation efficacy, triplicate defibrillation thresholds (DFTs) were determined before and after intravenous administration of 25% ethanol. Fifty-two pigs were randomized into four groups: (1) control, 6 mL/kg of saline over 10 minutes (n = 12); (2) low dose, 6 mL/kg of 25% ethanol over 10 minutes (n = 12); (3) mid dose, 0.45 mL/kg per minute for 30 minutes followed by 0.045 mL/kg per minute for 45 minutes (n = 12); and (4) high dose, 0.6 mL/kg per minute for 30 minutes followed by 0.06 mL/kg per minute for 45 minutes (n = 16). Three coil defibrillating electrodes (Medtronic 6888) were sutured to the epicardium of the right and left ventricles for defibrillation shocks. Ventricular fibrillation was induced using alternating current and after 10 seconds of fibrillation, the minimum energy for defibrillation was established using sequential pulse defibrillation. Triplicate determinations were obtained before and after saline or ethanol infusion. Alcohol elevated DFT in a dose related manner. Control and low dose groups thresholds were unchanged, but the mid dose approached statistical significance (6.8 +/- 0.7 vs 7.6 +/- 0.9 J, 0.05 < P < 0.1) and the high dose was significantly elevated (8.5 +/- 0.7 vs 11.2 +/- 1.1 J, P < 0.01). Ventricular effective refractory periods and cycle lengths between fibrillatory waves did not differ before and after the high dose ethanol.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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Y H Kim; D L Jones; A Natale; G J Klein |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: 16 ISSN: 0147-8389 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 1993 Jan |
Date Detail:
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Created Date: 1993-04-19 Completed Date: 1993-04-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 19-25 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Western Ontario, London, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiac Pacing, Artificial Defibrillators, Implantable Electric Countershock* Ethanol / blood, pharmacology* Heart Conduction System / drug effects*, physiopathology Swine* Ventricular Fibrillation / etiology, therapy* |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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