| Ethanol exposure during late gestation and nursing in the rat: effects upon maternal care, ethanol metabolism and infantile milk intake. | |
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MedLine Citation:
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PMID: 18602418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ethanol experiences, during late gestation as well as during nursing, modify the behavioral dynamics of the dam/pup dyad, and leads to heightened ethanol intake in the offspring. This study focuses on: a) behavioral and metabolic changes in intoxicated dams with previous exposure to ethanol during pregnancy and b) infantile consumption of milk when the dam is either under the effects of ethanol or sober. Pregnant rats received water, 1.0 or 2.0 g/kg ethanol, and were administered with water or ethanol during the postpartum period. Intoxication during nursing disrupted the capability of the dam to retrieve the pups and to adopt a crouching posture. These disruptions were attenuated when dams had exposure to ethanol during pregnancy. Ethanol experiences during gestation did not affect pharmacokinetic processes during nursing, whereas progressive postpartum ethanol experience resulted in metabolic tolerance. Pups suckling from intoxicated dams, with previous ethanol experiences, ingested more milk than did infants suckling from ethanol-intoxicated dams without such experience. Ethanol gestational experience results in subsequent resistance to the drug's disruptions in maternal care. Consequently, better maternal care by an intoxicated dam with ethanol experience during gestation facilitates access of pups to milk which could be contaminated with ethanol. |
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Authors:
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Mariana Pueta; Paula Abate; Olga B Haymal; Norman E Spear; Juan C Molina |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-06-17 |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 91 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-09-05 Completed Date: 2008-11-06 Revised Date: 2011-02-08 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: United States |
Other Details:
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Languages: eng Pagination: 21-31 Citation Subset: IM |
Affiliation:
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Instituto de Investigación Médica M. y M. Ferreyra (INIMEC - CONICET), Córdoba, C.P 5016, Argentina. mpueta@immf.uncor.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcoholic Intoxication
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psychology Animals Animals, Newborn / psychology* Animals, Suckling / psychology* Birth Weight / drug effects Central Nervous System Depressants / blood, metabolism*, toxicity* Ethanol / blood, metabolism*, toxicity* Female Lactation / physiology* Litter Size / drug effects Maternal Behavior / drug effects* Postpartum Period Pregnancy Rats Rats, Wistar Weight Gain / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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AA013098/AA/NIAAA NIH HHS; AA015992/AA/NIAAA NIH HHS; AA11960/AA/NIAAA NIH HHS; MH035219/MH/NIMH NIH HHS; R01 AA011960-07/AA/NIAAA NIH HHS; R01 AA011960-08/AA/NIAAA NIH HHS; R01 AA013098-06A1/AA/NIAAA NIH HHS; R01 AA015992-03/AA/NIAAA NIH HHS; R37 MH035219-20/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Depressants; 64-17-5/Ethanol |
| Comments/Corrections | |
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