Document Detail


Ethanol exposure during late gestation and nursing in the rat: effects upon maternal care, ethanol metabolism and infantile milk intake.
MedLine Citation:
PMID:  18602418     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ethanol experiences, during late gestation as well as during nursing, modify the behavioral dynamics of the dam/pup dyad, and leads to heightened ethanol intake in the offspring. This study focuses on: a) behavioral and metabolic changes in intoxicated dams with previous exposure to ethanol during pregnancy and b) infantile consumption of milk when the dam is either under the effects of ethanol or sober. Pregnant rats received water, 1.0 or 2.0 g/kg ethanol, and were administered with water or ethanol during the postpartum period. Intoxication during nursing disrupted the capability of the dam to retrieve the pups and to adopt a crouching posture. These disruptions were attenuated when dams had exposure to ethanol during pregnancy. Ethanol experiences during gestation did not affect pharmacokinetic processes during nursing, whereas progressive postpartum ethanol experience resulted in metabolic tolerance. Pups suckling from intoxicated dams, with previous ethanol experiences, ingested more milk than did infants suckling from ethanol-intoxicated dams without such experience. Ethanol gestational experience results in subsequent resistance to the drug's disruptions in maternal care. Consequently, better maternal care by an intoxicated dam with ethanol experience during gestation facilitates access of pups to milk which could be contaminated with ethanol.
Authors:
Mariana Pueta; Paula Abate; Olga B Haymal; Norman E Spear; Juan C Molina
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-06-17
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  91     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-09-05     Completed Date:  2008-11-06     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alcoholic Intoxication / psychology
Animals
Animals, Newborn / psychology*
Animals, Suckling / psychology*
Birth Weight / drug effects
Central Nervous System Depressants / blood,  metabolism*,  toxicity*
Ethanol / blood,  metabolism*,  toxicity*
Female
Lactation / physiology*
Litter Size / drug effects
Maternal Behavior / drug effects*
Postpartum Period
Pregnancy
Rats
Rats, Wistar
Weight Gain / drug effects
Grant Support
ID/Acronym/Agency:
AA013098/AA/NIAAA NIH HHS; AA015992/AA/NIAAA NIH HHS; AA11960/AA/NIAAA NIH HHS; MH035219/MH/NIMH NIH HHS; R01 AA011960/AA/NIAAA NIH HHS; R01 AA011960-07/AA/NIAAA NIH HHS; R01 AA011960-08/AA/NIAAA NIH HHS; R01 AA013098/AA/NIAAA NIH HHS; R01 AA013098-06A1/AA/NIAAA NIH HHS; R01 AA015992/AA/NIAAA NIH HHS; R01 AA015992-03/AA/NIAAA NIH HHS; R37 MH035219/MH/NIMH NIH HHS; R37 MH035219-20/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Central Nervous System Depressants; 3K9958V90M/Ethanol
Comments/Corrections

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