Document Detail

Ethanol exposure during either adolescence or adulthood alters the rewarding effects of cocaine in adult rats.
MedLine Citation:
PMID:  22366218     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The present studies assessed the effects of adolescent and adult ethanol exposure on the rewarding effects of cocaine as measured with the conditioned place preference procedure.
METHODS: Male rats were exposed to intraperitoneal (IP) injections of ethanol or vehicle for 10 days [postnatal days (PNDs) 30-39 or PNDs 70-79; 2 mg/kg]. Place preference conditioning began on PND 65 or PND 105, respectively, and consisted of a baseline test followed by four conditioning cycles with either 0, 5, 10 or 20 mg/kg cocaine. Following the fourth conditioning cycle a final preference test was performed. Changes in time on the drug-paired side between the baseline and final test were analyzed.
RESULTS: Animals exposed to vehicle (during adolescence or adulthood) showed a significant place preference at 20 mg/kg cocaine. Animals exposed to ethanol (during adolescence or adulthood) showed a significant place preference at 10mg/kg cocaine.
CONCLUSIONS: Exposure to ethanol (adolescents or adults) sensitized the rewarding effects of cocaine. This may indicate an increase in the abuse liability of cocaine following a history of ethanol exposure.
Mary Anne Hutchison; Anthony L Riley
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Publication Detail:
Type:  Journal Article     Date:  2012-02-15
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  101     ISSN:  1873-5177     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-03-21     Completed Date:  2012-08-02     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  458-64     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Cocaine / administration & dosage*
Cocaine-Related Disorders / etiology,  psychology
Conditioning (Psychology)
Disease Models, Animal
Dose-Response Relationship, Drug
Ethanol / administration & dosage*
Injections, Intraperitoneal
Rats, Sprague-Dawley
Reg. No./Substance:
3K9958V90M/Ethanol; I5Y540LHVR/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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