Document Detail

Ethanol disrupts and decreases the regulated body temperature differentially in C57BL/6J and DBA/2J mice.
MedLine Citation:
PMID:  9277557     Owner:  NLM     Status:  MEDLINE    
Two inbred mouse strains, C57BL/6J (B6) and DBA/2J (D2), were evaluated for effects of ethanol on thermoregulation. Continuous recording of core temperature (Tc) from undisturbed animals at an ambient temperature (Ta) of 27 degrees C indicated Tc was similar for both strains during active (approximately 38.0 degrees C) and inactive (approximately 36.7 degrees C) periods. Ethanol-injections of 1.5, 2.5, 3.5, and 4.5 g/kg in an environment where Ta rose and fell at 6-min intervals, reaching extremes of 14 and 42 degrees C, produced dose-dependent falls in Tc for both strains. The changes in Ta produced fluctuations in Tc under all conditions. The amplitude of these fluctuations in Tc was used as a measure of physiological disruption. Dose-dependent increases in disruption were found for both strains. At a constant 26 degrees C Ta, ethanol produced dose-related increases in tail temperature. Responses after ethanol administration were different for B6 and D2 mice. The results indicate regulated temperature is similar for B6 and D2 strains. Regulated temperature is decreased more by ethanol for B6 mice, whereas disruption of thermoregulation by ethanol is greater for D2 mice.
L I Crawshaw; H L Wallace; J C Crabbe; C Ramos; J Duerr; C S O'Connor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  273     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-25     Completed Date:  1997-09-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R696-702     Citation Subset:  IM    
Department of Biology and Environmental Science Program, Portland State University, Oregon 97207, USA.
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MeSH Terms
Body Temperature / drug effects
Body Temperature Regulation / drug effects*
Ethanol / pharmacology*
Mice, Inbred C57BL / physiology*
Mice, Inbred DBA / physiology*
Species Specificity
Grant Support
Reg. No./Substance:

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