Document Detail

Ethanol Locks to Prevent Catheter-Related Bloodstream Infections in Parenteral Nutrition: A Meta-Analysis.
MedLine Citation:
PMID:  22232307     Owner:  NLM     Status:  Publisher    
OBJECTIVE:Patients with pediatric intestinal failure (IF) depend on parenteral nutrition for growth and survival, but are at risk for complications, such as catheter-related bloodstream infections (CRBSIs). CRBSI prevention is crucial, as sepsis is an important cause of IF-associated liver disease and mortality. We aim to estimate the pooled effectiveness and safety of ethanol locks (ELs) in comparison with heparin locks (HLs) with regard to CRBSI rate and catheter replacements for pediatric IF patients with chronic parenteral nutrition dependence.METHODS:A systematic review without language restriction was performed on Medline (1948-2010), Embase (1980-2010), and conference programs and trial registries up to December 2010. Search terms included "Catheter-Related Infections," "Catheter," "Catheters, Indwelling," "alcohol," "ethanol," and "lock." Two authors identified 4 retrospective studies for the pediatric IF population. Double, independent data extraction using predefined data fields and risk of bias assessment (Newcastle-Ottawa scale) was performed.RESULTS:In comparison with HLs, ELs reduced the CRBSI-rate per 1000 catheter days by 7.67 events and catheter replacements by 5.07. EL therapy decreased the CRBSI rate by 81% and replacements by 72%. One hundred eight to 150 catheter days of EL exposure were necessary to prevent 1 CRBSI and 122 to 689 days of exposure avoided 1 catheter replacement. Adverse events were rare and included thrombotic events.CONCLUSIONS:In pediatric patients with IF, EL is a more effective alternative to HL. Adverse events include thrombotic events.
Carol Oliveira; Ahmed Nasr; Mary Brindle; Paul W Wales
Related Documents :
25158247 - Treatment gaps of epilepsy and retention rates of sodium valproate in rural guangxi, ch...
18673417 - Physiotherapeutic treatment improves oral opening in oral submucous fibrosis.
10768647 - Lower relapse rate of botulinum toxin a therapy for axillary hyperhidrosis by dose incr...
18704557 - Dermolipectomy of the thighs and buttocks to solve a massive silicone oil injection.
7796357 - A randomized comparative study on the safety and efficacy of clarithromycin and erythro...
20024167 - Demetalation kinetics of natural chlorophylls purified from oxygenic photosynthetic org...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-9
Journal Detail:
Title:  Pediatrics     Volume:  -     ISSN:  1098-4275     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aGroup for Improvement of Intestinal Function and Treatment (GIFT).
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Improving the quality of immunization delivery to an at-risk population: a comprehensive approach.
Next Document:  The Risk of Immune Thrombocytopenic Purpura After Vaccination in Children and Adolescents.