Document Detail


Ethanol Inhibits B16-BL6 Melanoma Metastasis and Cell Phenotypes Associated with Metastasis.
MedLine Citation:
PMID:  22210715     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: Every year, approximately 68,000 new cases of malignant melanoma are diagnosed in the US. Ethanol consumption inhibits metastasis of melanoma in mice, but the mechanism is not well understood.
MATERIALS AND METHODS: C57BL/6J ob/+ mice, given either water or 20% ethanol, were injected intravenously with B16-BL6 melanoma cells to determine pulmonary metastasis. The effects of ethanol on cell phenotypes and markers of the epithelial-to-mesenchymal transition were determined in cell culture.
RESULTS: In mice, ethanol consumption inhibited experimental pulmonary metastasis. This inhibition was associated with decreased body weight, and levels of systemic leptin, and insulin. In cell culture, ethanol inhibited B16-BL6 cell motility, invasion, and anchorage-independent growth. Additionally, ethanol reduced Snai1 expression and increased E-cadherin expression. Lastly, ethanol increased the expression of Kiss1 metastasis-suppressor and the metastasis suppressor Nm23/nucleoside diphosphate kinase.
CONCLUSION: In both animal and in cell culture conditions, ethanol inhibited the metastatic ability of B16-BL6 melanoma cells.
Authors:
Kyoko Kushiro; Nomelí P Núñez
Related Documents :
20631255 - Cdc42 regulates apical junction formation in human bronchial epithelial cells through p...
12777255 - Differential regulation of junctional complex assembly in renal epithelial cell lines.
1326565 - Inhibition of gap junction and adherens junction assembly by connexin and a-cam antibod...
16140775 - The extracellular domain of herpes simplex virus ge is indispensable for efficient cell...
22876125 - Wnt3a promotes epithelial-mesenchymal transition, migration, and proliferation of lens ...
8575465 - Localization of proteasomal antigens during different phases of the cell cycle in hela ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  26     ISSN:  1791-7549     ISO Abbreviation:  In Vivo     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  47-58     Citation Subset:  IM    
Affiliation:
1 University Station, A2703, Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX 78712, U.S.A. nomeli@mail.utexas.edu.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Gene Expression Changes Induced by HIPEC in a Murine Model of Gastric Cancer.
Next Document:  p53 Codon 72 Polymorphism in Oral Exfoliated Cells in a Sudanese Population.