Document Detail

Ethane production rate in vivo is reduced with dietary restriction.
MedLine Citation:
PMID:  2384436     Owner:  NLM     Status:  MEDLINE    
Dietary restriction without malnutrition prolongs life and has a beneficial effect on age-related diseases and metabolic derangements. To test the effect of food restriction on ethane production rate, ethane exhalation was measured in rats with partial food restriction. Ethane production rate in room air in rats fed 60% of food consumed by ad libitum-fed animals for 2 wk was significantly reduced (3.50 +/- 0.25 vs. 5.21 +/- 0.34 pmol.min-1.100 g body wt-1, P less than 0.01). In 100% oxygen, ethane production in food-restricted rats was not different from that of ad libitum-fed rats (21.81 +/- 1.25 vs. 19.57 +/- 1.89 pmol.min-1.100 g-1). Fifteen hours of fasting compared with ad libitum feeding reduced ethane production modestly in room air (4.37 +/- 0.45 vs. 5.21 +/- 0.34 pmol.min-1.100 g-1) and more significantly in 100% oxygen (12.37 +/- 0.78 vs. 19.57 +/- 1.89 pmol.min-1.100 g-1). Thus, in 100% oxygen, 15 h of fasting, compared with ad libitum feeding, resulted in an approximately 40% decrease in ethane production rate. It is concluded that short-term food restriction significantly reduces ethane exhalation rate in rats when measured in room air.
M P Habib; F Dickerson; A D Mooradian
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  68     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-09-18     Completed Date:  1990-09-18     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2588-90     Citation Subset:  IM    
Department of Medicine, College of Medicine, University of Arizona, Tucson.
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MeSH Terms
Energy Intake
Ethane / metabolism*
Free Radicals
Lipid Peroxidation
Rats, Inbred F344
Reg. No./Substance:
0/Free Radicals; 74-84-0/Ethane

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