Document Detail

Ethacrynic acid can be effective for refractory congestive heart failure and ascites.
MedLine Citation:
PMID:  14632366     Owner:  NLM     Status:  MEDLINE    
Ethacrynic acid is a loop diuretic little used today because of its side-effect profile and the availability of multiple alternative agents. However, in our clinical experience, ethacrynic acid can alleviate acute congestive heart failure and ascites resistant to other diuretics. Two patients aged 89 and 94 in life-threatening pulmonary edema were stabilized by ethacrynic acid after furosemide proved ineffective. A third patient, aged 83, with a pleural effusion and ascites secondary to end-stage hepatitis B and C, responded to ethacrynic acid when spironolactone and furosemide produced little urine output. Ethacrynic acid may have a unique niche as a diuretic of last resort, especially in geriatric practice.
Joseph M Alisky; Thomas F Tuttle
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  96     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-24     Completed Date:  2003-12-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1148-50     Citation Subset:  AIM; IM    
Division of General Internal Medicine, Marshfield Clinic, Marshfield Clinic Research Foundation, Marshfield, WI, USA.
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MeSH Terms
Aged, 80 and over
Ascites / drug therapy*
Diuretics / therapeutic use*
Ethacrynic Acid / therapeutic use*
Heart Failure / drug therapy*
Treatment Outcome
Reg. No./Substance:
0/Diuretics; 58-54-8/Ethacrynic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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