| Etanercept: an overview of dermatologic adverse events. | |
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MedLine Citation:
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PMID: 21242398 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objectives To provide a comprehensive overview of dermatologic adverse events of etanercept described in the literature (including all study types, case reports, and surveys) and to present information on the occurrence, severity, treatment, and course of these adverse events. Data Sources MEDLINE and EMBASE. Study Selection All reports on individual patients who developed a dermatologic adverse event associated with systemic etanercept treatment for any indication in any type of original article were included. Data Extraction All data were independently extracted by 2 reviewers. Disagreements were resolved by consensus. All articles included (except for case reports/case series) were assessed regarding level of evidence. Data Synthesis In 126 included study reports, a total of 72 separate specific dermatologic adverse events of etanercept were mentioned. In 101 case reports/case series, 153 individual patients with approximately 65 different specific diagnoses (eg, not rash) were reported. CONCLUSIONS: Etanercept is associated with a wide variety of dermatologic adverse events, many of which were described in study reports, but case reports also described numerous exceptional cases. Although the adverse events are usually mild, some reactions are serious and even potentially life threatening. Therefore, all drug-associated cutaneous abnormalities should be carefully evaluated. Diagnostic steps do not deviate from the norm in these patients, but management of the dermatologic adverse events may need special attention. |
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Authors:
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Lidian L A Lecluse; Emmilia A Dowlatshahi; C E Jacqueline M Limpens; Menno A de Rie; Jan D Bos; Phyllis I Spuls |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of dermatology Volume: 147 ISSN: 1538-3652 ISO Abbreviation: Arch Dermatol Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 79-94 Citation Subset: AIM; IM |
Affiliation:
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Department of Dermatology, Academic Medical Center, Room A0-229, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, the Netherlands. l.l.lecluse@amc.uva.nl. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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