| Etanercept-induced lupus accompanied by hemophagocytic syndrome. | |
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MedLine Citation:
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PMID: 21881286 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Hemophagocytic syndrome (HPS) is a severe, potentially life-threatening disorder characterized by an excessive activation of macrophages, such as may occur in the setting of lupus. A 62-year-old Japanese woman treated with etanercept for rheumatoid arthritis developed persistent fever, cytopenia, coagulopathy, and hyperferritinemia. Simultaneously, lupus-like features including pleuritis, hypocomplementemia, and positive autoantibodies were observed. She was diagnosed with HPS related to etanercept-induced lupus, and underwent immunosuppressive therapy with successful recovery. To our knowledge, this is the first case of etanercept-induced lupus accompanied by HPS. This case suggests that HPS should be considered as a complication during TNF-α inhibitor therapy. |
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Authors:
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Daisuke Araki; Hiroshi Fujii; Masami Matsumura; Masakazu Yamagishi; Akihiro Yachie; Mitsuhiro Kawano |
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Publication Detail:
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Type: Journal Article Date: 2011-09-01 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 50 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-09-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 1843-8 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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