Document Detail

Etanercept-induced anti-Jo-1-antibody-positive polymyositis in a patient with rheumatoid arthritis: a case report and review of the literature.
MedLine Citation:
PMID:  20143116     Owner:  NLM     Status:  MEDLINE    
Antitumor necrosis factor (TNF) therapy has been associated with adverse immunologic events including systemic lupus erythematosus. However, the development of polymyositis (PM)/dermatomyositis (DM) associated with anti-TNF therapy is extremely rare. We experienced a case of a 48-year-old female with rheumatoid arthritis (RA) who had anti-Jo-1 antibodies and interstitial lung disease but no previous history of PM/DM and who developed PM soon after the initiation of etanercept (ETN) therapy for RA. The patient recovered upon withdrawal from ETN and corticosteroid (CS) therapies. Only four reports of PM/DM associated with anti-TNF therapy for RA could be found in the literature. The patients described in three of the four reports were positive for anti-Jo-1 antibodies before the initiation of anti-TNF therapy, and in all the cases, recovery occurred after the cessation of anti-TNF-agent administration and CS therapy. These results suggest a relationship between the onset of PM/DM with anti-Jo-1 antibody and anti-TNF therapy for RA.
Yuki Ishikawa; Naoichiro Yukawa; Koichiro Ohmura; Yuji Hosono; Yoshitaka Imura; Daisuke Kawabata; Takaki Nojima; Takao Fujii; Takashi Usui; Tsuneyo Mimori
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-02-09
Journal Detail:
Title:  Clinical rheumatology     Volume:  29     ISSN:  1434-9949     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-07-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  563-6     Citation Subset:  IM    
Department of Rheumatology and Clinical Immunology, Kyoto University Hospital, Kyoto City, Kyoto, Japan.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Antibodies, Antinuclear / chemistry,  immunology*
Arthritis, Rheumatoid / complications*,  drug therapy*
Dermatomyositis / immunology
Immunoglobulin G / adverse effects*
Middle Aged
Polymyositis / drug therapy*,  immunology*
Receptors, Tumor Necrosis Factor
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antibodies, Antinuclear; 0/Immunoglobulin G; 0/Jo-1 antibody; 0/Receptors, Tumor Necrosis Factor; 185243-69-0/TNFR-Fc fusion protein
Comment In:
Clin Rheumatol. 2010 Jul;29(7):819-20   [PMID:  20405301 ]

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