Document Detail


Etanercept does not effectively treat moderate to severe alopecia areata: an open-label study.
MedLine Citation:
PMID:  15928633     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this prospective, open-label pilot study, we evaluated the safety and efficacy of etanercept, a TNF-alpha inhibitor, in the treatment of moderate to severe alopecia areata, alopecia totalis, or alopecia universalis. Seventeen otherwise healthy adults with moderate to severe alopecia areata were enrolled. The primary outcome measure was the extent of hair regrowth during and after the end of treatment as evaluated by the Severity of Alopecia Tool (the SALT score). After between 8 and 24 weeks of continuous treatment with etanercept 50 mg given subcutaneously twice weekly, significant regrowth of hair was not shown in any of the subjects treated. Based on these results, etanercept appears to be ineffective in treating subjects with treatment-refractory, moderate to severe alopecia areata, alopecia totalis, or alopecia universalis.
Authors:
Bruce E Strober; Kimberly Siu; Andrew F Alexis; Gene Kim; Ken Washenik; Animesh Sinha; Jerome L Shupack
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  52     ISSN:  1097-6787     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-01     Completed Date:  2006-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1082-4     Citation Subset:  IM    
Affiliation:
The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA. b_strober@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Alopecia Areata / drug therapy*
Female
Humans
Immunoglobulin G / therapeutic use*
Male
Middle Aged
Pilot Projects
Prospective Studies
Receptors, Tumor Necrosis Factor / therapeutic use*
Severity of Illness Index
Treatment Failure
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Immunoglobulin G; 0/Receptors, Tumor Necrosis Factor; 0/Tumor Necrosis Factor-alpha; 185243-69-0/TNFR-Fc fusion protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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