Document Detail


Estrous odors and sexually conditioned neutral odors activate separate neural pathways in the male rat.
MedLine Citation:
PMID:  12654349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Olfactory stimuli play important roles in sexual behavior. Previous studies have demonstrated that both estrous odors and initially neutral odors paired with copulation influence the sexual behavior of male rats. The present study examines the pattern of neural activation as revealed by Fos immunoreactivity (Fos-IR) following exposure to bedding scented with either a neutral odor (almond) paired previously with copulation, estrous odors or no odor. Following exposure to estrous odors Fos-IR increased in the accessory olfactory bulb, medial amygdala, medial bed nucleus of the stria terminalis, medial preoptic area, ventromedial hypothalamus, ventral tegmental area, and both the nucleus accumbens core and shell. Conversely, following exposure to the sexually conditioned odor Fos-IR increased in the piriform cortex, basolateral amygdala, nucleus accumbens core, and the anterior portion of the lateral hypothalamic area. In addition, following exposure to almond odor Fos-IR increased in the main olfactory bulb independent of its pairing with copulation. These patterns of Fos-IR following exposure to estrous or sexually conditioned odors were not influenced by either the addition or omission of the other type of odor. These findings demonstrate that estrous and sexually conditioned odors are processed by distinct neural pathways and converge in the nucleus accumbens core, suggesting that this structure has a unique role in processing sexual stimuli of both pheromonal and olfactory natures.
Authors:
T E Kippin; S W Cain; J G Pfaus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience     Volume:  117     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2003  
Date Detail:
Created Date:  2003-03-25     Completed Date:  2003-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  971-9     Citation Subset:  IM    
Affiliation:
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, QC, Montréal, Canada. tod.kippin@utoronto.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / cytology,  metabolism*
Conditioning (Psychology) / physiology*
Estrous Cycle / physiology*
Female
Immunohistochemistry
Limbic System / cytology,  metabolism
Male
Neural Pathways / cytology,  metabolism*
Nucleus Accumbens / cytology,  metabolism
Odors*
Proto-Oncogene Proteins c-fos / metabolism
Rats
Rats, Long-Evans
Sexual Behavior, Animal / physiology*
Smell / physiology*
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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