| Estrogens and the risk of complex regional pain syndrome (CRPS). | |
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MedLine Citation:
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PMID: 19111016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Since complex regional pain syndrome (CRPS) shows a clear female predominance, we investigated the association between the cumulative as well as current exposure to estrogens, and CRPS. METHODS: A population-based case-control study was conducted in the Integrated Primary Care Information (IPCI) project in the Netherlands. Cases were identified from electronic records (1996-2005) and included if they were confirmed during a visit (using International Association for the Study of Pain Criteria), or had been diagnosed by a specialist. Controls were matched to cases on gender, age, calendar time, and injury. Measures of cumulative endogenous estrogen exposure were obtained by questionnaire and included age of menarche and menopause, menstrual life, and cumulative months of pregnancy and breast-feeding. Current estrogen exposure at CRPS onset was retrieved from the electronic medical records and determined by current pregnancy or by the use of oral contraceptive (OC) drugs or hormonal replacement therapy (HRT). RESULTS: Hundred and forty-three female cases (1493 controls) were included in analyses on drug use and pregnancies, while cumulative endogenous estrogen exposure was studied in 53 cases (58 controls) for whom questionnaire data were available. There was no association between CRPS and either cumulative endogenous estrogen exposure, OC, or HRT use. CRPS onset was increased during the first 6 months after pregnancy (OR: 5.6, 95%CI: 1.0-32.4), although based on small numbers. DISCUSSION: We did not find an association between CRPS onset and cumulative endogenous estrogen exposure or current OC or HRT use, but more powered studies are needed to exclude potential minor associations. |
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Authors:
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M de Mos; F J P M Huygen; B H Ch Stricker; J P Dieleman; M C J M Sturkenboom |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacoepidemiology and drug safety Volume: 18 ISSN: 1099-1557 ISO Abbreviation: Pharmacoepidemiol Drug Saf Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-05 Completed Date: 2009-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9208369 Medline TA: Pharmacoepidemiol Drug Saf Country: England |
Other Details:
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Languages: eng Pagination: 44-52 Citation Subset: IM |
Affiliation:
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Pharmaco-Epidemiology Unit, Department of Medical Informatics and Epidemiology & Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands. m.vrolijk-demos@erasmusmc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Aged Case-Control Studies Complex Regional Pain Syndromes / epidemiology, etiology* Contraceptives, Oral / adverse effects Estrogen Replacement Therapy / adverse effects Estrogens / administration & dosage, adverse effects*, metabolism Female Humans Lactation / metabolism Menarche / metabolism Menopause / metabolism Middle Aged Netherlands / epidemiology Pregnancy Questionnaires Risk Factors Sex Factors Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral; 0/Estrogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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