Document Detail


Estrogens and male reproduction: a new concept.
MedLine Citation:
PMID:  17581673     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mammalian testis serves two main functions: production of spermatozoa and synthesis of steroids; among them estrogens are the end products obtained from the irreversible transformation of androgens by a microsomal enzymatic complex named aromatase. The aromatase is encoded by a single gene (cyp19) in humans which contains 18 exons, 9 of them being translated. In rats, the aromatase activity is mainly located in Sertoli cells of immature rats and then in Leydig cells of adult rats. We have demonstrated that germ cells represent an important source of estrogens: the amount of P450arom transcript is 3-fold higher in pachytene spermatocytes compared to gonocytes or round spermatids; conversely, aromatase activity is more intense in haploid cells. Male germ cells of mice, bank voles, bears, and monkeys express aromatase. In humans, we have shown the presence of a biologically active aromatase and of estrogen receptors (alpha and ss) in ejaculated spermatozoa and in immature germ cells in addition to Leydig cells. Moreover, we have demonstrated that the amount of P450arom transcripts is 30% lower in immotile than in motile spermatozoa. Alterations of spermatogenesis in terms of number and motility of spermatozoa have been described in men genetically deficient in aromatase. These last observations, together with our data showing a significant decrease of aromatase in immotile spermatozoa, suggest that aromatase could be involved in the acquisition of sperm motility. Thus, taking into account the widespread localization of aromatase and estrogen receptors in testicular cells, it is obvious that, besides gonadotrophins and androgens, estrogens produced locally should be considered to be physiologically relevant hormones involved in the regulation of spermatogenesis and spermiogenesis.
Authors:
S Carreau; D Silandre; S Bourguiba; K Hamden; L Said; S Lambard; I Galeraud-Denis; C Delalande
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  40     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-21     Completed Date:  2008-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  761-8     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University of Caen, Caen, France. serge.carreau@unicaen.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Aromatase / genetics,  physiology*
Estrogen Receptor alpha / physiology
Estrogen Receptor beta / physiology
Estrogens / biosynthesis*,  genetics
Gene Expression Regulation
Humans
Male
Reproduction / physiology*
Spermatogenesis / physiology
Spermatozoa / chemistry,  enzymology
Testis / cytology,  metabolism*,  physiology
Chemical
Reg. No./Substance:
0/Estrogen Receptor alpha; 0/Estrogen Receptor beta; 0/Estrogens; EC 1.14.14.1/Aromatase

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