Document Detail

Estrogens and the Leydig LTW(m) tumor syndrome: anorexia and diet aversions attenuated by area postrema lesions.
MedLine Citation:
PMID:  3467386     Owner:  NLM     Status:  MEDLINE    
The development of learned aversions to the available diet has been shown to contribute to the anorexia and weight loss which accompany the growth of certain tumors, including the Leydig LTW(m) tumor. Estradiol infusions were found to closely mimic the effects on food intake and food preference seen after Leydig LTW(m) tumor implants. That is, reductions in food intake and the development of severe aversions to a target diet available during hormone infusions were seen. Lesions of the area postrema greatly attenuated these effects of estradiol infusions. Similar lesions have been shown to have parallel effects on the LTW(m) tumor syndrome. These findings strongly implicate the elevations of circulating estrogens which accompany the growth of LTW(m) tumors in generating the symptoms of anorexia and diet aversions.
I L Bernstein; L Courtney; D J Braget
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  38     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1986  
Date Detail:
Created Date:  1987-02-10     Completed Date:  1987-02-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  159-63     Citation Subset:  IM    
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MeSH Terms
Anorexia / etiology*,  physiopathology
Eating / drug effects
Eating Disorders / etiology*
Estradiol / pharmacology
Estrogens / physiology*
Food Preferences / drug effects
Leydig Cell Tumor / complications*,  physiopathology
Neoplasm Transplantation
Neurosecretory Systems / physiopathology*
Rats, Inbred WF
Grant Support
Reg. No./Substance:
0/Estrogens; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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