| Estrogenic compounds suppressed interferon-gamma production in mouse splenocytes through direct cell-cell interaction. | |
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MedLine Citation:
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PMID: 14602042 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Here, we reported the effects of 17beta-estradiol (E2), isoflavone genistein (Gen), and daidzein (Dai) on the production of interferon (IFN)-gamma by splenocytes isolated from C57BL/6N mice. When mouse splenocytes were stimulated with lipopolysaccharide, E2, Gen, and Dai suppressed the production of IFN-gamma. However, when only nonadherent cell populations of splenocytes were tested, none of these estrogenic compounds suppressed IFN-gamma production. This result indicates that IFN-gamma production by nonadherent cell populations of splenocytes treated with estrogens is regulated by adherent cell populations. Moreover, direct cell-cell interaction between both populations was necessary for suppression of IFN-gamma production by nonadherent populations. In addition, E2 conjugated with bovine serum albumin inhibited IFN-gamma production as well as E2. This result suggests that the plasma membrane-associated estrogen receptor plays a prominent role in this suppression mechanism. |
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Authors:
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Mako Nakaya; Masao Yamasaki; Yoshiyuki Miyazaki; Hirofumi Tachibana; Koji Yamada |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: In vitro cellular & developmental biology. Animal Volume: 39 ISSN: 1071-2690 ISO Abbreviation: In Vitro Cell. Dev. Biol. Anim. Publication Date: 2003 Sep-Oct |
Date Detail:
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Created Date: 2004-03-24 Completed Date: 2004-08-12 Revised Date: 2013-06-11 |
Medline Journal Info:
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Nlm Unique ID: 9418515 Medline TA: In Vitro Cell Dev Biol Anim Country: United States |
Other Details:
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Languages: eng Pagination: 383-7 Citation Subset: IM |
Affiliation:
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Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. makorenu@agr.kyushu-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cattle Cell Adhesion / physiology Cell Communication / physiology* Cells, Cultured Estradiol / analogs & derivatives*, pharmacology Estrogen Antagonists / pharmacology Estrogens / pharmacology* Genistein / metabolism Interferon-gamma / metabolism* Isoflavones / metabolism Male Mice Mice, Inbred C57BL Receptors, Estrogen / metabolism Spleen / cytology*, drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Estrogen Antagonists; 0/Estrogens; 0/Isoflavones; 0/Receptors, Estrogen; 22X328QOC4/fulvestrant; 446-72-0/Genistein; 50-28-2/Estradiol; 6287WC5J2L/daidzein; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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