Document Detail


Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-α interactions with G protein-αi and caveolin I.
MedLine Citation:
PMID:  22230296     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSIONS: Xenoestrogens, like physiologic estrogens, can evoke downstream kinase signaling involving selective interactions of ERα with G(αi) and caveolin I, but with some different characteristics, which could explain their disruptive actions.
Authors:
Cheryl S Watson; Yow-Jiun Jeng; Guangzhen Hu; Ann Wozniak; Nataliya Bulayeva; Jutatip Guptarak
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-12-30
Journal Detail:
Title:  Steroids     Volume:  77     ISSN:  1878-5867     ISO Abbreviation:  Steroids     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-14     Completed Date:  2012-08-14     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  424-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzhydryl Compounds
Caveolae / metabolism
Caveolin 1 / genetics,  metabolism*
Cell Line, Tumor
Cell Membrane / metabolism
Estrogen Receptor alpha / genetics,  metabolism*
Estrogens / pharmacology*
Estrogens, Non-Steroidal / pharmacology
Extracellular Signal-Regulated MAP Kinases / metabolism
GTP-Binding Protein alpha Subunits, Gi-Go / genetics,  metabolism*
Guanosine Triphosphate / metabolism
Immunoblotting
MAP Kinase Signaling System / drug effects*
Microscopy, Fluorescence
Oligonucleotide Array Sequence Analysis
Phenols / pharmacology*
Pituitary Neoplasms / genetics,  metabolism,  pathology
Protein Binding / drug effects
Rats
Grant Support
ID/Acronym/Agency:
R01 ES015292/ES/NIEHS NIH HHS; R01 ES015292-03/ES/NIEHS NIH HHS; R01 ES015292-04/ES/NIEHS NIH HHS; R01 ES015292-04S1/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Benzhydryl Compounds; 0/Caveolin 1; 0/Estrogen Receptor alpha; 0/Estrogens; 0/Estrogens, Non-Steroidal; 0/Phenols; 25154-52-3/nonylphenol; 86-01-1/Guanosine Triphosphate; EC 2.7.11.24/Extracellular Signal-Regulated MAP Kinases; EC 3.6.5.1/GTP-Binding Protein alpha Subunits, Gi-Go; MLT3645I99/bisphenol A
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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