| Estrogen and retinoic acid antagonistically regulate several microRNA genes to control aerobic glycolysis in breast cancer cells. | |
| | |
MedLine Citation:
|
PMID: 23064179 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In addition to estrogen receptor modulators, retinoic acid and other retinoids are promising agents to prevent breast cancer. Retinoic acid and estrogen exert antagonistic regulations on the transcription of coding genes and we evaluated here whether these two compounds have similar effects on microRNAs. Using an integrative approach based on several bioinformatics resources together with experimental validations, we indeed found that retinoic acid positively regulates miR-210 and miR-23a/24-2 expressions and is counteracted by estrogen. Conversely, estrogen increased miR-17/92 and miR-424/450b expressions and is inhibited by retinoic acid. In silico functional enrichment further revealed that this combination of transcriptional/post-transcriptional regulations fully impacts on the molecular effects of estrogen and retinoic acid. Besides, we unveiled a novel effect of retinoic acid on aerobic glycolysis. We specifically showed that it increases extracellular lactate production, an effect counteracted by the miR-210 and the miR-23a/24-2, which simultaneously target lactate dehydrogenase A and B mRNAs. Together our results provide a new framework to better understand the estrogen/retinoic acid antagonism in breast cancer cells. |
| | |
Authors:
|
Anne Saumet; Guillaume Vetter; Manuella Bouttier; Etienne Antoine; Christine Roubert; Beatrice Orsetti; Charles Theillet; Charles-Henri Lecellier |
Related Documents
:
|
4030759 - Metabolism of all-trans-retinoic acid and all-trans-retinyl acetate. demonstration of c... 8592069 - All-trans-retinoic acid regulates retinol and 3,4-didehydroretinol metabolism in cultur... 7097369 - The biological activity of retinotaurine. 3383129 - Cystathionine metabolism in neuroblastoma. 8947589 - Ethacrynic acid and 1 alpha,25-dihydroxyvitamin d3 cooperatively inhibit proliferation ... 3566789 - The formation of all-trans-retinoic acid from all-trans-retinol in hairless mouse skin. 111779 - Effect of neonatal malnutrition on leucine renewal and protein biosynthesis in neurons ... 2873929 - Lipid esterification and secretion by the mouse intestine in organ culture. 6261899 - Control of fat cell phosphohydrolase by lipolytic agents. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-12 |
Journal Detail:
|
Title: Molecular bioSystems Volume: - ISSN: 1742-2051 ISO Abbreviation: Mol Biosyst Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101251620 Medline TA: Mol Biosyst Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
INSERM U896, F-34298Montpellier, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Novel bio-active lipid nanocarriers for the stabilization and sustained release of sitosterol.
Next Document: The Need for a Systematic Approach to Statin Switching: An Analysis of Real-World Experience.