| Estrogen replacement therapy and progression of intimal-medial thickness in the carotid arteries of postmenopausal women. ACAPS Investigators. Asymptomatic Carotid Atherosclerosis Progression Study. | |
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MedLine Citation:
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PMID: 7485045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of estrogen replacement therapy (ERT) on 3-year changes in carotid intimal-medial thickness (IMT) was explored using serial B-mode ultrasound measurements collected during 1989-1993 as part of the Asymptomatic Carotid Atherosclerotic Progression Study (ACAPS). Eligibility included increased IMT and elevated low density lipoprotein cholesterol. Of the 186 postmenopausal ACAPS women randomly assigned to receive either placebo or lovastatin, 34% reported use of ERT. Users tended to be younger than nonusers by an average of 3 years, to have more favorable high and low density lipoprotein cholesterol levels, and to be more likely to have had hysterectomies. Baseline blood pressure, body mass index, and cross-sectional IMT were similar among ERT users and nonusers. In the placebo group, IMT tended to progress among ERT nonusers but to regress among ERT users: Mean covariate-adjusted progression rates were 0.015 +/- 0.007 mm/year versus -0.012 +/- 0.012 mm/year, respectively (p = 0.05). This difference appeared to be independent of lipoprotein concentrations. Lovastatin was associated with an approximately 25% lowering of low density lipoprotein cholesterol among both ERT users and nonusers and had a marked impact on IMT progression (p = 0.004) in these women. ERT appeared to have little additional effect on IMT in women assigned to lovastatin. ERT may reduce or halt the progression of early atherosclerosis in women not receiving active lipid-lowering medication. |
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Authors:
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M A Espeland; W Applegate; C D Furberg; D Lefkowitz; L Rice; D Hunninghake |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of epidemiology Volume: 142 ISSN: 0002-9262 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1995-12-14 Completed Date: 1995-12-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1011-9 Citation Subset: IM |
Affiliation:
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Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, NC 27157-1063, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anticholesteremic Agents / therapeutic use* Arteriosclerosis / prevention & control*, ultrasonography Carotid Artery Diseases / prevention & control*, ultrasonography Cholesterol, HDL / blood Cholesterol, LDL / blood Estrogen Replacement Therapy* Female Humans Lovastatin / therapeutic use* Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR-02802/RR/NCRR NIH HHS; R01-HL-38194/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 75330-75-5/Lovastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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