Document Detail

Estrogen replacement therapy improves baroreflex regulation of vascular sympathetic outflow in postmenopausal women.
MedLine Citation:
PMID:  11413079     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Menopausal estrogen loss has been associated with increased cardiovascular disease in postmenopausal women. However, the link between estrogen and cardiovascular disease remains unclear. Some data suggest estrogen mediates its effect through changes in arterial pressure and its regulation. However, the data available in older women are equivocal regarding estrogen's ability to reduce resting arterial pressure or to improve its regulation. METHODS AND RESULTS: We studied 11 healthy, postmenopausal women before and after 6 months of estrogen administration. Arterial pressure was measured by brachial auscultation and finger photoplethysmography. Vascular sympathetic nerve activity was measured in the peroneal nerve by microneurography, and the slope of the relations between changes in heart period, sympathetic activity, and arterial pressure caused by bolus infusions of nitroprusside and phenylephrine were used as an index of baroreflex gain. Estrogen therapy did not change systolic pressure (128+/-2 versus 123+/-2 mm Hg) or cardiac-vagal baroreflex gain (6.6+/-0.9 versus 6.7+/-0.7 ms/mm Hg). However, vascular sympathetic baroreflex gain was increased (-4.6+/-0.6 versus -7.4+/-1.0 arbitrary integrated units/mm Hg; P=0.02). CONCLUSION: These findings suggest long-term estrogen replacement therapy has effects on cardiovascular regulation that may not be reflected in resting arterial pressures.
B E Hunt; J A Taylor; J W Hamner; M Gagnon; L A Lipsitz
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  103     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-19     Completed Date:  2001-07-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2909-14     Citation Subset:  AIM; IM    
Laboratory for Cardiovascular Research, Research and Training Institute, Hebrew Rehabilitation Center for Aged, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
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MeSH Terms
Administration, Oral
Baroreflex / drug effects*,  physiology
Blood Pressure / drug effects
Drug Administration Schedule
Estrogen Replacement Therapy*
Estrogens / administration & dosage
Heart Rate / drug effects
Infusions, Intravenous
Middle Aged
Nitroprusside / administration & dosage
Peroneal Nerve / drug effects,  physiology
Progesterone / administration & dosage
Supine Position / physiology
Vagus Nerve / drug effects,  physiology
Vasomotor System / drug effects*,  physiology
Grant Support
Reg. No./Substance:
0/Estrogens; 15078-28-1/Nitroprusside; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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