| Estrogen replacement therapy for depression in perimenopausal women. | |
| | |
MedLine Citation:
|
PMID: 19810294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine the effect of a four-week course of oral estrogen therapy on depression in aging women. DESIGN: Quasi experimental. PLACE AND DURATION OF STUDY: The OPD, Bahawal Victoria Hospital, Bahawalpur, from September 2000 to January 2004. PATIENTS AND METHODS: Forty-two depressed women (aged 42-57) who were either perimenopausal (n = 20) or postmenopausal (n = 22) received open label treatment with oral estrogen tablets (1.25 mg/day) for 4 weeks. The Montgomery-Asberg Depression Rating Scale and the Beck Depression Inventory were used to assess depressive symptoms, the Greene Climacteric Scale was used to assess menopause-related symptoms, and the Clinical Global Impression(CGI) was used to assess global clinical improvement in these women at baseline and after treatment. Remission of depression was defined as a score < 10 on the Montgomery-Asberg Depression Rating Scale and a score < or = 2 on the CGI at week 4. RESULTS: The women who completed the study had a median Montgomery-Asberg Depression Rating Scale score of 20 (range = 15-32) at study entry and 11.50 (range = 10-31.0) at week 4 (z = -3.43, p < 0.01). This improvement was consistent with that reported by the women themselves on the Beck Depression Inventory (rs = 0.86, n = 20, p < 0.01). The improvement measured by CGI scores was also significant (p < 0.01). Remission of depression was noted in 5 of the 40 women (after 1 year) who completed the study. Anti-depressant response was not associated with severity or subtypes of depression at study entry or with concomitant improvement in menopause-related symptoms. CONCLUSION: Perimenopausal and postmenopausal women benefit from short-term use of estrogen therapy. Antidepressant effect of estrogen therapy is independent of improvement in menopause-related symptoms. |
| | |
Authors:
|
Asma Shaukat; Tariq Mahmud Arain; Amna Shahid; Shahid Irfan; Soufia Farrukh |
Related Documents
:
|
1486774 - Use of a monophasic, low-dose oral contraceptive in relation to mental functioning. 16020404 - The effects of remifemin on subjective symptoms of menopause. 23438654 - Safety in pharmacological enhancement of stroke rehabilitation. 21349204 - A randomised, feasibility trial of a tele-health intervention for acute coronary syndro... 1486774 - Use of a monophasic, low-dose oral contraceptive in relation to mental functioning. 16437504 - Antifungal agents for preventing fungal infections in non-neutropenic critically ill pa... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Volume: 15 ISSN: 1022-386X ISO Abbreviation: J Coll Physicians Surg Pak Publication Date: 2005 Oct |
Date Detail:
|
Created Date: 2009-10-08 Completed Date: 2009-11-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9606447 Medline TA: J Coll Physicians Surg Pak Country: Pakistan |
Other Details:
|
Languages: eng Pagination: 597-600 Citation Subset: IM |
Affiliation:
|
Department of Pathology, Quaid-i-Azam Medical College, Bahawalpur. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Depression / drug therapy* Estrogen Replacement Therapy* Female Humans Middle Aged Perimenopause Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The outcome of subtotal abdominal hysterectomy.
Next Document: Comparison of unfractionated heparin vs low molecular weight heparin in the treatment of acute deep ...