Document Detail

Estrogen receptors in the central auditory system of male and female mice.
MedLine Citation:
PMID:  19925852     Owner:  NLM     Status:  MEDLINE    
The estrogen receptors in the central auditory system of male and female mice were characterized using immunocytochemical methods. Estrogen receptors alpha and beta (ERalpha, ERbeta) were localized predominantly in the ventral cochlear nucleus, nucleus of the trapezoid body, the lateral- and medio-ventral periolivary nuclei, the dorsal lateral lemniscus, and the inferior colliculus. The medial geniculate nucleus was negative for both ERalpha and ERbeta whereas the auditory cortex was positive for ERalpha. The lateral superior olive, the ventral lateral lemniscus and the central nucleus of the inferior colliculus expressed only ERbeta. The differential localization of ERalpha and ERbeta may indicate distinct roles for these two receptors in auditory processing. No major differences in the pattern, number or intensity of receptor expression was found between male and female animals. The comprehensive anatomic map that is constructed for ERalpha and ERbeta in the central auditory pathway will be a useful foundation to elucidate the complexity of estrogen actions in the auditory system.
K Charitidi; B Canlon
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-20
Journal Detail:
Title:  Neuroscience     Volume:  165     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-03-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  923-33     Citation Subset:  IM    
Copyright Information:
Copyright 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
Department of Physiology and Pharmacology, Karolinska Institute, Stockholm 171 77, Sweden.
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MeSH Terms
Aromatase / metabolism
Auditory Pathways / anatomy & histology,  enzymology,  metabolism*
Blotting, Western
Brain / anatomy & histology,  enzymology,  metabolism*
Estrogen Receptor alpha / metabolism*
Estrogen Receptor beta / metabolism*
Estrous Cycle
Hormones / metabolism
Mice, Inbred CBA
Sex Characteristics*
Reg. No./Substance:
0/Estrogen Receptor alpha; 0/Estrogen Receptor beta; 0/Hormones; EC

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