Document Detail

Estrogen receptors are essential for female sexual receptivity.
MedLine Citation:
PMID:  8977441     Owner:  NLM     Status:  MEDLINE    
One of the most important, robust and evolutionarily conserved functions for neural estrogen receptor (ER) is as a mediator of female sexual behavior. Using homozygotic ER knockout (ERKO) mice we tested the hypothesis that ER controls female receptivity. Females with either two normal copies of the ER gene (wild-types), or an insertational disruption (knockouts) of the ER were ovariectomized. Each female was treated with 17 beta-estradiol (EB) alone, and with EB in combination with progesterone, prior to tests for behavioral receptivity. Under both hormonal conditions female ERKO mice did not display sexual receptivity whereas wild-type litter-mates were receptive to males. Male behavior indicated that females of both genotypes were equally attractive. Brain tissues were examined with immunocytochemical methods showed that ERKOs had greatly reduced levels of ER immunoreactivity in hypothalamus. In sum, the data show that ER is required for the display of sexual receptivity, but is not essential for female attractivity.
E F Rissman; A H Early; J A Taylor; K S Korach; D B Lubahn
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrinology     Volume:  138     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-01-23     Completed Date:  1997-01-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  507-10     Citation Subset:  AIM; IM    
Department of Biology, University of Virginia, Charlottesville 22903, USA.
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MeSH Terms
Mice, Inbred C57BL
Mice, Knockout
Receptors, Estrogen / genetics,  physiology*
Sexual Behavior, Animal*
Grant Support
Reg. No./Substance:
0/Receptors, Estrogen

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