| Estrogen receptor subtype-specific effects on markers of bone homeostasis. | |
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MedLine Citation:
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PMID: 18433985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To further elucidate the processes involved in the physiology of bone-protection by estrogens, ovariectomized (OVX) rats were treated subcutaneously with 17beta-estradiol (E(2)), the ERalpha-specific agonist (16alpha-LE2) and the ERbeta-specific agonist (8beta-VE2). OVX and intact animals served as controls. Biomarkers of bone-formation (osteocalcin (OC), osteopontin (OPN)) and bone-resorption (telopeptides of collagen type I (CTx), pyridinoline cross-links (Pyd)) were quantified. Bone mineral density was measured by computed tomography. OVX-induced bone loss could be antagonized by subcutaneous administration of 17beta-estradiol and 16alpha-LE2. Serum levels of CTx, OC and OPN were significantly elevated in OVX compared to intact animals and reduced by 17beta-estradiol and 16alpha-LE2. Treatment of OVX rats with 8beta-VE2 did not affect bone mineral density (BMD) or bone-marker serum levels. Taken together, the complex expression pattern of bone-markers in OVX rats following subcutaneous administration of ER subtype-specific agonists indicates that 17beta-estradiol exerts its bone-protective effects by modulating the activity of osteoclasts and osteoblasts via ERalpha. |
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Authors:
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T Hertrampf; B Schleipen; M Velders; U Laudenbach; K H Fritzemeier; P Diel |
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Publication Detail:
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Type: Journal Article Date: 2008-03-16 |
Journal Detail:
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Title: Molecular and cellular endocrinology Volume: 291 ISSN: 0303-7207 ISO Abbreviation: Mol. Cell. Endocrinol. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-05 Completed Date: 2008-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: Ireland |
Other Details:
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Languages: eng Pagination: 104-8 Citation Subset: IM |
Affiliation:
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Institut für Kreislaufforschung und Sportmedizin, Abt. molekulare und zelluläre Sportmedizin, DSHS Köln, Germany. hertrampf@dshs-koeln.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / metabolism* Bone Density Bone and Bones / metabolism* Estradiol / metabolism Estrogen Receptor alpha / agonists, genetics, metabolism* Estrogen Receptor beta / agonists, genetics, metabolism* Female Homeostasis Molecular Structure Organ Size Ovariectomy Random Allocation Rats Uterus / anatomy & histology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Estrogen Receptor alpha; 0/Estrogen Receptor beta; 50-28-2/Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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