| Estrogen receptor in rabbit endocervical cells isolated by velocity sedimentation. | |
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MedLine Citation:
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PMID: 6466756 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three nonciliated rabbit endocervical epithelial cell types were isolated by velocity sedimentation at unit gravity. Cell Types I and II contained heterogeneous secretory granules, whereas Type III cells were characterized by empty cytoplasmic vacuoles. Previous studies had confirmed the ultrastructural and functional integrity of each cell type and suggested hormone dependence of cell population sizes. Since the concentration of total cytosol estrogen receptor in endocervical epithelial cells from progesterone-dominated, 5-day pseudopregnant rabbits was reduced to approximately 23% of the value for estrous rabbits, receptor concentrations were measured in the three nonciliated epithelial cell types from animals in both hormonal states. The results indicate that the reduction in the estrogen receptor content in progesterone-dominated animals can be attributed to a reduction in the number of Type I and Type II cells, and to a significant (P less than 0.05) reduction in their estrogen receptor concentrations. |
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Authors:
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B S Chilton |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biology of reproduction Volume: 31 ISSN: 0006-3363 ISO Abbreviation: Biol. Reprod. Publication Date: 1984 Aug |
Date Detail:
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Created Date: 1984-10-25 Completed Date: 1984-10-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0207224 Medline TA: Biol Reprod Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 213-20 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Separation Centrifugation Cervix Uteri / analysis*, cytology, ultrastructure Cytoplasmic Granules Female Gravitation Leucine / metabolism Pronase / pharmacology Pseudopregnancy / pathology Rabbits Receptors, Estrogen / analysis* |
| Grant Support | |
ID/Acronym/Agency:
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HD-16676/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Estrogen; 61-90-5/Leucine; EC 3.4.24.-/Pronase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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