Document Detail


Estrogen receptor gene amplification occurs rarely in ovarian cancer.
MedLine Citation:
PMID:  18690166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Amplification of the gene encoding estrogen receptor-alpha occurs in about 20% of breast cancers and is an important mechanism for estrogen receptor overexpression in this tumor type. In ovarian cancer, overexpression of estrogen receptor protein has been described in more than two thirds of cases. To study a potential role of estrogen receptor-alpha gene amplification for estrogen receptor overexpression in ovarian cancer, a tumor tissue microarray containing 428 ovarian cancers was analyzed by fluorescence in situ hybridization for estrogen receptor-alpha gene amplification and immunohistochemistry for estrogen receptor expression. The estrogen receptor-alpha gene status was successfully determined in 243 of 428 arrayed cancers. Estrogen receptor gene amplification was found in 5 of 243 (2%) of tumors. Amplification levels were usually low, with 4-8 estrogen receptor-alpha gene copies. However, one case had a high-level amplification, with more than 30 estrogen receptor-alpha gene copies. All five amplified tumors were estrogen receptor positive, with 3 of 5 tumors showing highest (Allred score, 7-8) estrogen receptor levels. The data demonstrate that estrogen receptor-alpha amplification occurs only rarely in ovarian cancer.
Authors:
Rana M Issa; Annette Lebeau; Tobias Grob; Frederik Holst; Holger Moch; Luigi Terracciano; Matthias Choschzick; Guido Sauter; Ronald Simon
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Publication Detail:
Type:  Journal Article     Date:  2008-08-08
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  22     ISSN:  1530-0285     ISO Abbreviation:  Mod. Pathol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-30     Completed Date:  2009-04-30     Revised Date:  2011-04-21    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  191-6     Citation Subset:  IM    
Affiliation:
Department of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Estrogen Receptor alpha / analysis,  genetics*
Female
Gene Amplification*
Gene Expression Regulation, Neoplastic*
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Kaplan-Meier Estimate
Middle Aged
Ovarian Neoplasms / chemistry,  genetics*,  mortality
Prognosis
Tissue Array Analysis
Young Adult
Chemical
Reg. No./Substance:
0/Estrogen Receptor alpha; 0/estrogen receptor alpha, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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