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Estrogen receptor beta and melanoma. A comparative study.
MedLine Citation:
PMID:  23013061     Owner:  NLM     Status:  Publisher    
Background:  oncological research has been focused on evaluating estrogen receptors (ERs) in estrogen-related tumors and understanding the potential role of ERs in the pathophysiology of cancer. Objectives:  To investigate the significance of estrogen receptor beta (ERβ) in melanoma. Methods:  We prospectively evaluated ERβ expression in malignant melanoma (MM) tissue and adjacent healthy skin by quantitative immunohistochemistry at the Department of Dermatology of the University of Florence from 1998 to 2010. Results:  ERβ was detected with varying staining intensity in the 66 malignant melanocytic lesions. After adjusting for age and gender, we found that ERβ expression was significantly lower in melanoma tissue compared with adjacent healthy skin (P < 0.0001). We also found significantly lower ERβ levels in thick melanoma tissue compared with thin melanoma tissue. In addition, there was a positive association between Breslow thickness and the difference of ERβ expression between healthy tissue and melanoma tissue (P = 0.0004). Consistent with gender differences in melanoma survival, men showed significantly lower levels of ERβ than women in both melanoma and healthy tissues (P = 0.05 and 0.02, respectively). Conclusions:  ERβ expression is inversely associated with Breslow thickness and also significantly influenced by gender in MM.
V de Giorgi; A Gori; S Gandini; F Papi; M Grazzini; S Rossari; A Simoni; V Maio; D Massi
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-26
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 British Association of Dermatologists.
Department of Dermatology, University of Florence, Florence, Italy Clinical Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy Department of Human Pathology and Oncology, University of Florence, Florence, Italy.
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