Document Detail

Estrogen and progesterone receptors in neoplastic cells of metastatic pleural effusion of breast carcinoma before and after tamoxifen therapy. Correlation with the clinical response.
MedLine Citation:
PMID:  3769044     Owner:  NLM     Status:  MEDLINE    
We have investigated the activity of tamoxifen in 12 post-menopause patients affected by advanced breast carcinoma and, in this specific case, by metastatic pleural effusion. A receptor assay was carried out on all patients to assess the estrogen and progesterone receptor activity in pleural effusion tumor cells, cytologically confirmed. The assay was performed both at the moment of the diagnostic check and after a week of 30 mg/die of tamoxifen therapy. We obtained a temporary reduction of the pleural effusion in 5 patients out of 12 (42%). Four out of these 5 patients presented estrogen receptors (ER+) at the first assay. In the 4 patients with negative receptors (ER-) neither a decrease of the percentage of tumoral cells, nor a reduction of the effusion was ascertained. This study shows that also for pleural effusions tamoxifen's therapeutic benefit was obtainable only in those patients with estrogen receptors in the tumoral cells.
D Di Lorenzo; A Zaniboni; E Simoncini; P Marpicati; E Montini; A Alghisi; F Gorni; G Marini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemioterapia : international journal of the Mediterranean Society of Chemotherapy     Volume:  5     ISSN:  0392-906X     ISO Abbreviation:  Chemioterapia     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-11-25     Completed Date:  1986-11-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8401667     Medline TA:  Chemioterapia     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  232-6     Citation Subset:  IM    
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MeSH Terms
Breast Neoplasms / drug therapy*
Estradiol / analysis
Middle Aged
Pleural Effusion / etiology,  metabolism*
Pleural Neoplasms / analysis,  complications,  drug therapy,  secondary*
Radioligand Assay
Receptors, Estrogen / analysis*
Receptors, Progesterone / analysis*
Tamoxifen / therapeutic use*
Reg. No./Substance:
0/Receptors, Estrogen; 0/Receptors, Progesterone; 10540-29-1/Tamoxifen; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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