Document Detail

Estrogen and osteoarthritis.
MedLine Citation:
PMID:  15005596     Owner:  NLM     Status:  MEDLINE    
In menopausal women and the elderly, populations most often affected by osteoarthritis (OA), estrogen levels are lower than normal, which suggests that estrogen may be an important regulator of OA. Estrogen can influence chondrocyte function on multiple levels by interacting with cellular growth factors, adhesion molecules, and cytokines. Nevertheless, findings regarding a correlation between estrogen and OA are inconsistent and inconclusive and range from estrogen protecting against OA to cartilage damage mediated by high levels of estrogen and higher binding to estrogen receptors. In this review, we summarize current in vivo and in vitro research and discuss future directions for analyses of the role of estrogen in OA.
Jayashree A Gokhale; Sally R Frenkel; Paul E Dicesare
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of orthopedics (Belle Mead, N.J.)     Volume:  33     ISSN:  1078-4519     ISO Abbreviation:  Am J. Orthop.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-09     Completed Date:  2004-06-03     Revised Date:  2010-01-05    
Medline Journal Info:
Nlm Unique ID:  9502918     Medline TA:  Am J Orthop (Belle Mead NJ)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  71-80     Citation Subset:  IM    
Musculoskeletal Research Center, Department of Orthopaedics, Hospital for Joint Diseases, New York, New York, USA.
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MeSH Terms
Cell Adhesion Molecules / physiology
Chondrocytes / physiology
Estrogen Replacement Therapy
Estrogens / physiology*
Insulin-Like Growth Factor I / physiology
Intercellular Adhesion Molecule-1 / physiology
Osteoarthritis / physiopathology*
Receptors, Estrogen / physiology
Transforming Growth Factor beta / physiology
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Estrogens; 0/Receptors, Estrogen; 0/Transforming Growth Factor beta; 126547-89-5/Intercellular Adhesion Molecule-1; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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