Document Detail


Estrogen is necessary for 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats.
MedLine Citation:
PMID:  18786558     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The progesterone metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP, allopregnanolone), acts in the ventral tegmental area (VTA) to facilitate exploratory, anti-anxiety, and socio-sexual behavior among ovariectomized (OVX), estrogen (E(2))-primed rats and gonadally-intact rats with high (proestrus) or low (diestrus) endogenous E(2) levels. The extent to which E(2) is required for these effects of 3alpha,5alpha-THP is not known. OVX rats were primed with systemic 17beta-estradiol (10 microg) or oil vehicle and were infused 44 h later with 3alpha,5alpha-THP (100 ng) or beta-cyclodextrin vehicle to the VTA, substantia nigra (SN), or central grey (CG). Rats were assessed in a battery of exploratory (open field), anxiety (elevated plus maze), social (partner preference, social interaction), and sexual (paced mating) tasks. E(2)-priming was necessary for 3alpha,5alpha-THP infusions to facilitate social interaction and mating and midbrain 3alpha,5alpha-THP levels were higher among E(2)-compared to vehicle-primed rats. Irrespective of E(2)-priming, rats infused with 3alpha,5alpha-THP to the VTA, but not SN or CG, demonstrated increased exploration in an open field, anti-anxiety behavior on an elevated plus maze, and preference for a male. Thus, actions of 3alpha,5alpha-THP in the VTA to enhance social and sexual behaviors were reliant on E(2) but increases in exploratory and anti-anxiety behavior were not.
Authors:
C A Frye; J J Paris; M E Rhodes
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-08-23
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  91     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-10-30     Completed Date:  2009-01-06     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  261-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Affect / drug effects*
Aggression / drug effects,  psychology
Animals
Anxiety / psychology
Appetitive Behavior / drug effects
Desoxycorticosterone / administration & dosage,  analogs & derivatives*,  pharmacology
Estradiol / blood,  pharmacology
Estrogens / blood,  pharmacology,  physiology*
Exploratory Behavior / drug effects*
Female
Microinjections
Neurosecretory Systems / drug effects,  physiology
Ovariectomy*
Posture
Radioimmunoassay
Rats
Rats, Long-Evans
Sexual Behavior, Animal / drug effects*
Social Behavior*
Steroids / pharmacology
Ventral Tegmental Area / physiology*
Grant Support
ID/Acronym/Agency:
MH06769801/MH/NIMH NIH HHS; R01 MH067698/MH/NIMH NIH HHS; R01 MH067698-01A2/MH/NIMH NIH HHS; R01 MH067698-02/MH/NIMH NIH HHS; R01 MH067698-03/MH/NIMH NIH HHS; R01 MH067698-04/MH/NIMH NIH HHS; R01 MH067698-05/MH/NIMH NIH HHS; R56 MH067698/MH/NIMH NIH HHS; R56 MH067698-06/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Estrogens; 0/Steroids; 40GP35YQ49/Desoxycorticosterone; 4TI98Z838E/Estradiol; 567-03-3/tetrahydrodeoxycorticosterone
Comments/Corrections

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