Document Detail

Estrogen induction of fatty liver in dairy cattle.
MedLine Citation:
PMID:  2384618     Owner:  NLM     Status:  MEDLINE    
Two trials were conducted to determine if estrogen contributes to development of fatty liver in dairy cattle. During trial 1, eight late lactation, nonpregnant cows were assigned to 0 or 15 mg estradiol-17 beta benzoate/d treatment. Days 1 to 3 of the trial were for baseline measurements, and treatments were given from d 4 to 21; on d 20 and 21 animals were fasted. Short-term feed deprivation resulted in increased plasma FFA concentrations and rapid accumulation of triglyceride into liver tissue obtained by biopsy. During starvation, plasma FFA concentration and liver triglyceride content were lower for cows receiving the estradiol-17 beta treatment relative to cows receiving control treatment. Very low density lipoprotein concentration in blood increased dramatically in three of four animals during estradiol-17 beta administration. Because of the decrease in milk production during estradiol-17 beta treatment, it was not known whether this represented a decrease in very low density lipoprotein clearance from blood or reflected a lipotropic response to estradiol-17 beta. Therefore, a second trial was conducted employing nonlactating cows, and control and estradiol-17 beta-treated animals were pair fed. The trial was 33 d with d 1 to 3 for baseline measurements, and treatments were administered from d 4 to 33. All animals were starved from d 19 to 23. Estradiol-17 beta increased hepatic lipid and triglyceride accumulation and plasma very low density lipoprotein concentration during starvation. Plasma FFA concentration was also increased by estradiol-17 beta during this time; therefore, a direct or indirect effect of estrogen on hepatic lipid metabolism could not be delineated.
R R Grummer; S J Bertics; D W Lacount; J A Snow; M R Dentine; R H Stauffacher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of dairy science     Volume:  73     ISSN:  0022-0302     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-09-18     Completed Date:  1990-09-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1537-43     Citation Subset:  IM    
Department of Dairy Science, University of Wisconsin, Madison 53706.
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MeSH Terms
Cattle Diseases / chemically induced*
Estradiol / adverse effects*
Fatty Acids, Nonesterified / blood
Fatty Liver / chemically induced,  veterinary*
Food Deprivation / physiology
Lipids / analysis
Liver / analysis
Triglycerides / analysis,  blood
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Lipids; 0/Triglycerides; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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